| Aplastic Crisis Secondary to Parvovirus B19 Infection |
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Yang Joon Park, Dae Kyun Koh, Jin Hee Oh |
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Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea |
| Parvovirus B19 감염으로 발생된 Aplastic Crisis 3례 |
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박양준, 고대균, 오진희 |
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가톨릭대학교 의과대학 소아과학교실 |
Correspondence:
Dae Kyun Koh, Email: kdk7016@hanmail.net
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| Abstract |
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Human parvovirus(HPV) B19 infection causes erythema infectiosum in children, sometimes red cell aplastic crisis with hemolytic anemia and chronic bone marrow failure in immunocompromised hosts. HPV B19 is directly cytotoxic for erythroid progenitor cells and inhibits erythropoiesis. Infrequently, HPV B19 inhibits hematopoiesis of three cell lineages and causes transient pancytopenia in patients with hemolytic disorders. We report three patients with hereditary spherocytosis who developed transient aplastic crisis. A HPV B19 infection was confirmed by IgM anti-B19 parvovirus titers and characteristic findings of bone marrow examination as the causative agent associated with severe pancytopenia. Three patients recovered spontaneously after a short period of supportive care with red cell transfusions and intravenous immunoglobulin. |
| Key Words:
Aplastic Crisis, Parvovirus B19, Hereditary spherocytosis |
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