| A study of neonatal cholestasis and cytomegalovirus infection. |
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Moon A Kim, Ki Sup Chung |
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Department of Pediatrics, College of Medicine, Yonsei University, Seoul, Korea |
| 거대세포바이러스 감염에 의한 신생아
담즙정체증에 관한 연구 |
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김문아, 정기섭 |
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연세대학교 의과대학 소아과학교실 |
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Received: 7 July 1989 • Accepted: 7 July 1989 |
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| Abstract |
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A clinical assessment of 25 patients with neonatal cholestasis caused by cytomegalovirus infection
who were admitted to the Department of Pediatrics, Yonsei University College of Medicine from
January 1983 to July 1988 was performed.
The results were as follows:
1) The patients with neonatal cholestasis caused by cytomegalovirus infection were 19% of the
total patients with neonatal cholestasis from January 1983 to July 1988 and were over 30% annually
since 1987.
2) Among 25 cases, 21 cases were neonatal hepatitis, 2 cases biliary atresia and the remaining 2
cases neonatal hepatitis with biliary atresia.
3) Seventy six percent of the patients were 2—3 months of age and 13 cases were male and 12 cases
were female.
4) Thirty two percent of the patients were low birth weight infants and 18% were premature
neonates.
5) Hepatomegaly was present in all 25 cases. Jaundice and splenomegaly were noted in 96%, and
acholic stool was noted in 56%. Congenital anomalies were noted in 12% of the patients.
6) There were no statistical differences in laboratory findings between the patients with acholic
stool and those without.
7) Among 23 cases who were treated medically, 14 cases improved, 7 cases deteriorated and 2 cases
died. Two cases who received Kasai operation died during the follow up period.
8) During the follow up period <1 〜 24 months), 28% of the patients recovered, 28% progressively
improved, 4% progressively deteriorated, 4% were stationary, and 16% died.
9) The proposed prognostic factors such as gestational age over 37 weeks, birth weight above 2.5
kg, age of onset of jaundice over 2 weeks after birth and absence of cirrhotic change were related to
a favorable outcome even though statistically insignificant. In contrast, patients with acholic stool or
biliary atresia were associated with poor prognosis with statistical significance. |
| Key Words:
Neonatal Cholestasis, Cytomegalovirus Infection |
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