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A Case of Kikuchi-Fujimoto Disease, Subsequently Evolving to Systemic Lupus Eyrthematosus

Korean Journal of Pediatrics 2004;47(8):904-907.
Published online August 15, 2004.
A Case of Kikuchi-Fujimoto Disease, Subsequently Evolving to Systemic Lupus Eyrthematosus
Soon Hwa Yoon1, Myoung Hoon Song1, Seon Hee Shin1, Sung Koo Kim1, Kon Hee Lee1, Hae Sun Yoon1, Young Ok Jung2, Hye Kyung Ahn3
1Department of Pediatrics, College of Medicine, Hallym University, Seoul, Korea
2Department of Internal Medicine, College of Medicine, Hallym University, Seoul, Korea
3Department of Pathology, College of Medicine, Hallym University, Seoul, Korea
Kikuchi병으로부터 진행된 전신성 홍반성 낭창 1례
윤순화1, 송명훈1, 신선희1, 김성구1, 이건희1, 윤혜선1, 정영옥2, 안혜경3
1한림대학교 의과대학 소아과학교실
2한림대학교 의과대학 내과학교실
3한림대학교 의과대학 임상병리학교실
Correspondence: 
Soon Hwa Yoon, Email: ysh1027@orgio.net
Abstract
Kikuchi-Fujimoto disease(KFD), also known as histiocytic necrotizing lymphadenitis, is a self-limited systemic illness and it has the pathognomonic histological appearance of lymph nodes. KFD is rarely associated with systemic lupus erythematosus (SLE). The diagnosis of KFD can precede, postdate or coincide with the diagnosis of SLE. Our case describes a young woman, originally diagnosed as having Kikuchi's disease by lymph node histology, who subsequently developed SLE with constitutional symptoms, skin rash, hematologic and immunologic disorder and high titer of antinuclear antibody. This raises consideration for the proposal that KFD may reflect a SLE-like auto-immune condition. Patients with KFD should be kept under observation for several years for the development of SLE. And KFD should be ruled out in SLE flare-up accompanied by lymphadenopathy.
Key Words: Kikuchi-Fujimoto disease, Histiocytic necrotizing lymphadenitis, Systemic lupus erythematosus


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