| Cord blood Cytokines on the Development of Cerebral Palsy in Premature Infant |
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Ki Dae Kim, Byeong Hee Son, Chang Whan Oh, Jung A Lee, Sung Won Kim |
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Department of Pediatrics, St. Benedict Hospital, Busan, Korea |
| 미숙아에서 뇌성마비 발생과 제대혈 Cytokine에 대한 연구 |
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김기대, 손병희, 오창환, 이정아, 김성원 |
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성분도병원 소아과 |
Correspondence:
Byeong Hee Son, Email: pedson40@yahoo.co.kr
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| Abstract |
Purpose
: This study was performed to determine the relation between cord blood plasma cytokines responses and development of cerebral palsies in premature infants.
Methods
: Interleukin-1β(IL-1β), Interleukin-6(IL-6), Tumor necrosis factor-α(TNF-α) were measured using ELISA kits in premature infants(n=60) who were admitted to St. Benedict Hospital from September 2001 to June 2003. Retrospective study was done by review of medical records.
Results
: Cord blood levels of IL-1β, IL-6 and TNF-α in the cerebral palsy group were higher, especially IL-6 but were not significant, compared with the control group. Cord blood levels of IL-6 in the cerebral palsy without asphyxia, sepsis, PROM, RDS and pneumonia were significantly different, compared with the control group.
Conclusion
: Cord blood levels of IL-1β, IL-6 and TNF-α in the cerebral palsy group were increased, but concentrations of IL-6 increased significantly. Cord blood levels of IL-6 may be a useful value to predict the development of cerebral palsy, because they are related to IL-6 rather than to TNF-α & IL-1β in this study. |
| Key Words:
Cytokine, Interlukin(IL-1β, IL-6, TNF-α), Cerebral palsy, Premature |
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