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A Case of Aplastic Anemia following Hepatic Failure by Acute Hepatitis

Korean Journal of Pediatrics 2004;47(12):1356-1359.
Published online December 15, 2004.
A Case of Aplastic Anemia following Hepatic Failure by Acute Hepatitis
Hye Jin Ku, Young Tak Lim, Jae Hong Park
Department of Pediatrics, Pusan National University College of Medicine, Pusan, Korea
급성 간염에 의한 간부전증에 병발된 재생불량성 빈혈 1례
구혜진, 임영탁, 박재홍
부산대학교 의과대학 소아과학교실
Correspondence: 
Jae Hong Park, Email: jhongpark@pusan.ac.kr
Abstract
Aplastic anemia following acute hepatitis or acute hepatic failure is an uncommon disease and has a poor prognosis. We experienced a case of aplastic anemia following acute hepatic failure in a 10- year-old girl. She was admitted because of jaundice and lethargy for 8 days. Laboratory findings revealed marked elevated serum transaminases and bilirubin levels, prolonged prothrombin time and partial thromboplastin time, and massive hepatic necrosis on the pathological study. There was no evidence of metabolic, toxic or autoimmune hepatitis. During the treatment of acute hepatic failure, pancytopenia developed and marked hypocellularity of all hematopoietic elements in bone marrow was revealed. She recovered partially from aplastic anemia after treatment with anti-thymocyte globulin, corticosteroid and cyclosporine.
Key Words: Acute hepatitis, Acute hepatic failure, Aplastic anemia


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