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Affecting Factors of Insulin Resistance in Obese Children and Adolescents

Korean Journal of Pediatrics 2005;48(10):1076-1081.
Published online October 15, 2005.
Affecting Factors of Insulin Resistance in Obese Children and Adolescents
Duk Hee Kim1, Ho Seon Eun1, In Kyung Choi1, Ho Seung Kim1, Bong Soo Cha2, Dong Kee Kim3
1Department of Pediatrics, College of Medicine, Yonsei University, Seoul, Korea
2Department of Internal Medicine, College of Medicine, Yonsei University, Seoul, Korea
3Department of Medical Statistics, College of Medicine, Yonsei University, Seoul, Korea
소아 및 청소년 비만증에서 인슐린 저항성에 미치는 요인
김덕희1, 은호선1, 최인경1, 김호성1, 차봉수2, 김동기3
1연세대학교 의과대학 소아과학교실
2연세대학교 의과대학 내과학교실
3연세대학교 의과대학 의학통계학과
Duk Hee Kim, Email: dhkim3@yumc.yonsei.ac.kr
: Insulin resistance is the most important risk factor linked to the development of impaired glucose tolerance(IGT), diabetes mellitus and cardiovascular diseases in childhood and adolescent obesity, The purpose of this study was to see whether insulin resistance of obese adolescent is higher than that of obese children. and to analyze gender difference and affecting factors of insulin resistance.
: Of the 9,837 school children from 5 to 16 tears old, 92 obese children and 187 adolescent, underwent a two-hour oral glucose tolerance test and plasma glucose, insulin, lipid profiles, leptin and high sensitive C-reactive protein(hs-CRP) were measure.
: Plasma insulin levels of female were higher compared to those of males during oral glucose tolerance test(P<0.05). Four(4.3%) in obese children and twenty five(13.3%) in obese adolescents met the criteria of IGT. Female, leptin, adiponectin and triglyceride concentrations were strongly correlated with homeostatic model assessment insulin-resistance(HOMA-IR) by multiple linear regression analysis(P<0.05).
: Obese adolescents might have higher insulin concentrations compared to obese children and obese girls higher insulin concentrations than obese boys. Obese boys and children with impaired glucose tolerance have higher insulin concentrations than those with normal glucose tolerance. HOMA-IR was significantly correlated with female, plasma leptin, adiponectin and triglyceride concentrations.
Key Words: Childhood obesity , Adolescent obesity , Insulin resistance , Impaired glucose tolerance

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