Korean Journal of Pediatrics 2006;49(6):665-671.
Published online June 15, 2006.
Effects of growth hormone treatment on glucose metabolism in idiopathic short stature
Seung Yeon Kwon, Duk-Hee Kim, Ho-Seong Kim
Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea
특발성 저신장증 환자에서 성장 호르몬 투여가 당 대사에 미치는 영향
권승연, 김덕희, 김호성
연세대학교 의과대학 소아과학교실
Correspondence: 
Duk-Hee Kim, Email: dhkim@yumc.yonsei.ac.kr
Abstract
Purpose
: To study the effects of growth hormone(GH) treatment on glucose metabolism and insulin resistance in children with idiopathic short stature(ISS).
Methods
: Glucose and insulin concentrations were measured during oral glucose tolerance test (OGTT) before and after GH treatment(0.6-0.7 IU/kg/week) in 20 patients with ISS. Insulin resistance was assessed by homeostasis model assessment(HOMA).
Results
: During OGTT, the mean blood glucose level did not show any significant changes after GH treatment. However, mean blood insulin levels of fasting and 30 minutes of OGTT showed significant increases after GH treatment, accompanying significant increases of insulin resistance. There was no difference in change of glucose, insulin levels and insulin resistance before and after GH treatment between two groups of body mass indices(BMI) of 25< and >25. There also was no significant difference between two groups of with and without family histories of diabetes mellitus (DM). There was no case of newly developed impaired glucose tolerance, fasting glucose tolerance, nor newly developed DM.
Conclusion
: GH treatment with doses of 0.6-0.7 IU/kg/week for mean 9.6 months in patients with ISS did not show any significant changes in blood glucose levels during OGTT. However, GH treatments induced considerably higher fasting insulin levels compared to pretreatment, resulting in statistically higher insulin resistance. Higher BMI and family history of DM did not induce any significant changes in glucose, insulin level and insulin resistance after GH treatment than the other groups.
Key Words: Growth hormone , Glucose metabolism , Insulin resistance , Idiopathic short stature


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