| The effects of human growth hormone on short stature. |
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Sang Mi Ha, Duk Hi Kim |
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Department of Pediatrics, College of Medicine, Yonsei University, Seoul, Korea |
| 왜소증에서 성장호르몬의 투여 효과 |
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하상미, 김덕희 |
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연세대학교 의과대학 소아과학교실 |
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Received: 26 February 1991 • Accepted: 24 May 1991 |
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| Abstract |
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Since Raben’s original report that human growth hormone promoted growth in a boy with pituitary
dwarfism, the hormone’s efficacy in children with growth hormone deficiency has been amply
confirmed. However the scarcity of growth hormone prepared human pituitaries has limited studies
of its usefulness in short stature. The availability of a biologically active human growth hormone
produced by recombinant-DNA technology has dramatically changed the therapeutic prospects for
children with short stature.
Thirty four boys and 25 girls aged 4.5 to 16.5 years were treated with human growth hormone for
6 to 50 months. During growth hormone therapy, yearly growth was increased from 5.55 cm to 7.22
cm in the first 6 months and 7.31 cm in the first year. The effects of growth hormone were found to
be the most effective in aged between 10 to 14 years and more effective in male than female.
And there were significant negative correlations between height velocity and pretreatment height
velocity and bone age, respectively.
The authors concluded that effects of human growth hormone on short stature were significant, and
there would be some more studies on factors that effect growth and its adverse effects. |
| Key Words:
Short stature, Human growth hormone |
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