| Effect of Oxandrolone Therapy in Short Stature. |
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Yil Sub Lee, Soo Young Lee, Duk Hi Kim |
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Department of Pediatrics, Yonsei University, College of Medicine, Seoul, Korea |
| 왜소증에서 Oxandrolone의 치료 효과 |
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이일섭, 이수영, 김덕희 |
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연세대학교 의과대학 소아과학교실 |
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Received: 27 February 1989 • Accepted: 24 April 1989 |
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| Abstract |
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Fifty six boys and 28 girls aged 4 to 15.8 years were treated with oxandrolone during the 4 to 25
months. Measurement of height and bone age were made at the beginning and at 6 months intervals.
The daily dose were 0.08 mg to 0.28 mg per kilogram. Predictions for adult height at the beginning of
the study were compared with those at the end of the treatment period.
The height velocity was increased 0.14 cm to 0.79 cm per month, height age was increased, and bone
age was increased, but height age/bone age was not changed. There was no difference in height
velocity between growth hormone dificient and normal variant short stature. The oxandrolone was
most effective in aged 10 to 12 years, more effective in male than female. There was a increase of
predicted adult height 157.3 cm to 158.8 cm.
The oxandrolone increased plasma somatomedine C level. But the results were not confirmed
obviously and needed for the further long term follow up. |
| Key Words:
Oxandolone therapy, Short stature |
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