| Effects of Antenatal Indomethacin on Neonate. |
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Ja Ye Kim1, Seung Joo Lee2, Keun Lee2 |
1Department of Pediatrics,Kangnam Sacred Hospital, Hallym Colledge
2Department of Pediatrics, Colledge of Mecidine, Ewha Womans University |
| 임산부에게 투여한 Indomethacin이 신생아에게 미치는 영향 |
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김자예1, 이승주2, 이근2 |
1한림의대부속 강남성심병원 소아과학교실
2이화대학교 의과대학 소아과학교실 |
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| Abstract |
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Prostaglandins play an important role in mediating uterine contractions and thus may also be involved in the triggering of premature labor and spontaneous abortion. Consequently inhibition of prostaglandin synthesis has been suggested as a potential means of inhibiting premature labor. There are many controlled studies which have described the use of indomethacin for inhibition of premature labor with success. But there may be
possible toxicity of antenatal indomethacin on the fetus and neonate such as premature closure of ductus arteriosus, pulmonary hypertension, hemorrhagic diasthesis, kernicterus and acute renal failure. Here we studied the potential side effects of antenatal indomethacin on the neonates. The results are as follows:
1)The increase in BUN, serum creatinine level and the decrease in creatinine clearence, urine volume are statistically significant in the study group. And the incidence of acute renal failure in the study group is significantly increased. 2)The incidence of PFC and the need for artificial ventilator is significantly increased
in study group. 3) The bleeding time, platelet count and bleeding diasthesis are not significantly different
between two groups. 4)There is no significant difference in onset time and duration of jaundice and peak
bilirubin level between two groups.
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| Key Words:
Antenatal indomethacin, Prostaglandin, Uterine contraction, Side effects |
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