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Immune thrombocytopenic purpura(ITP)

Korean Journal of Pediatrics 2006;49(8):830-832.
Published online August 15, 2006.
Immune thrombocytopenic purpura(ITP)
Hee Young Shin
Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea
면역 혈소판감소 자색반병
서울대학교 의과대학 소아과학교실
Hee Young Shin, Email: hyshin@plaza.snu.ac.kr
Immune thrombocytopenic purpura(ITP) is an autoimmune disease characterized by increased peripheral platelet destruction due to antibody to platelet, which results in thrombocytopenia and cutaneous or mucosal bleeding. Bleeding generally occurs when platelet counts fall to less than 20,000/µL. Children affected with ITP are usually healthy prior to the onset of the disease and typically present suddenly after a viral infection or insidiously with progressive petechiae, bruising, or purpura. In most cases the disease is self-limited; approximately 80% of children recover by 6 months after diagnosis, with or without treatment. Children with thrombocytopenia persisting for more than 6 months are defined as having chronic ITP. Clinical manifestations, diagnosis, laboratory findings, differential diagnosis and various treatment modalities are reviewed.
Key Words: Thrombocytopenia , Immune , Idiopathic , Acute , Chronic , Platelet , Antibody

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