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Relationship of serum IL-13 and eotaxin level with airway hyperresponsiveness in children with asthma

Korean Journal of Pediatrics 2006;49(8):889-894.
Published online August 15, 2006.
Relationship of serum IL-13 and eotaxin level with airway hyperresponsiveness in children with asthma
Eun Young Park, Jung Yeon Shim, Myung Hwan Yoo, Deok Soo Kim, Jae Won Shim, Hye Lim Jung, Moon Soo Park
Department of Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seou
소아 천식 환아에서 혈청 IL-13 및 eotaxin 농도와 기관지과민성의 관계
박은영, 심정연, 유명환, 김덕수, 심재원, 정혜림, 박문수
성균관대학교 의과대학 강북삼성병원 소아과
Jung Yeon Shim, Email: jyssim@hotmail.com
: Asthma is characterized by the presence of airway hyperresponsiveness(AHR) and inflammation. The extensive eosinophil infiltration into the lung is the hallmark of asthma and contributes to the damage of respiratory epithelium during late phase airway responses. Eotaxin is the major eosinophil chemoattractant found in bronchoalveolar lavage(BAL) fluid of allergic inflammation. IL-13 has been known to induce the expression of exotaxin and eosinophilia. IL-13 also induces airway inflammation, mucus production and leads to marked fibrosis, airway remodeling and AHR. We investigated whether serum IL-13 levels can reflect the presence of airway hyperresponsiveness in children with asthma, and the relationship between serum IL-13 and eotaxin levels.
: Using sandwich enzyme-linked immunosorbent assay, the serum IL-13 and eotaxin levels were measured in 13 atopic asthmatics, 5 atopic non-asthmatics and 12 control subjects. Metacholine challenge tests were performed in all subjects. Airway hyperresponsiveness to metacholine was expressed as provocative concentration of metacholine causing a 20% fall in FEV1[PC20 mg/mL]. PC20 value of 25 mg/mL was used as a cut-off for defining a AHR.
: Serum IL-13 levels showed positive correlation with eotaxin levels. Serum IL-13 and eotaxin levels showed no differences among atopic asthmatics, atopic non-asthmatics and control subjects. And there were no differences serum IL-13 and eotaxin levels in children with and without AHR and atopy. Serum IL-13 and eotaxin levels did not correlate with logPC20 levels.
: IL-13 is closely related to the eotaxin release. But serum IL-13 and eotaxin per se can't predict the severity of airway hyperresponsiveness. IL-13 and eotaxin may have local effect on respiratory epithelium or there can be some factors to induce airway hyperresponsiveness other than serum IL-13 in asthmatic airways.
Key Words: Asthma , Airway hyperresponsiveness , Interleukin-13 , Eotaxin

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