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Fever

Korean Journal of Pediatrics 2007;50(2):121-126.
Published online February 15, 2007.
Fever
Taek Jin Lee, Dong Soo Kim
Department of Pediatrics, Yonsei University College of Medicine, Severance Children's Hospital, Seoul, Korea
발 열
이택진, 김동수
연세대학교 의과대학 소아과학교실
Correspondence: 
Dong Soo Kim, Email: dskim6634@yumc.yonsei.ac.kr
Abstract
Fever has been recognized as a cardinal feature of disease since antiquity, but only recently has the pathophysiology of fever come to be understood. It became clear that the ultimate cause of fever is not a bacterial product (a so-called exogenous pyrogen) but a product of host inflammatory cells (i.e., an endogenous pyrogen). Many studies have demonstrated that mononuclear phagocytes are the principal source of endogenous pyrogen and that a variety of mononuclear cell products can mediate the febrile response. Cytokines are also important as mediators of the acute-phase response to infection and inflammation.
Key Words: Fever


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