| Fever |
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Taek Jin Lee, Dong Soo Kim |
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Department of Pediatrics, Yonsei University College of Medicine, Severance Children's Hospital, Seoul, Korea |
| 발 열 |
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이택진, 김동수 |
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연세대학교 의과대학 소아과학교실 |
Correspondence:
Dong Soo Kim, Email: dskim6634@yumc.yonsei.ac.kr
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| Abstract |
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Fever has been recognized as a cardinal feature of disease since antiquity, but only recently has the pathophysiology of fever come to be understood. It became clear that the ultimate cause of fever is not a bacterial product (a so-called exogenous pyrogen) but a product of host inflammatory cells (i.e., an endogenous pyrogen). Many studies have demonstrated that mononuclear phagocytes are the principal source of endogenous pyrogen and that a variety of mononuclear cell products can mediate the febrile response. Cytokines are also important as mediators of the acute-phase response to infection and inflammation. |
| Key Words:
Fever |
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