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Serum interleukin-6, tumor necrosis factor-α and adiponectin levels in Kawasaki disease

Korean Journal of Pediatrics 2010;53(1):41-47.
Published online January 15, 2010.
Serum interleukin-6, tumor necrosis factor-α and adiponectin levels in Kawasaki disease
Jung Ahn, Han Gyu Kim, Sejung Sohn, Young Mi Hong
Department of Pediatrics, Ewha Womans University, School of Medicine, Seoul, Korea
가와사키병 환자의 혈청 interleukin-6, tumor necrosis factor-α, Adiponectin 치에 대한 연구
안정, 김한규, 손세정, 홍영미
이화여자대학교 의과전문대학원 소아과학교실
Young Mi Hong, Tel: +82.2-2650-2841, Fax: +82.2-2653-3718, Email: ymhong@ewha.ac.kr
: Adiponectin is an endogenous modulator of vascular remodeling that suppresses vascular inflammation. However, the role of adiponectin in Kawasaki disease (KD) has not been elucidated. The purpose of this study is to investigate the correlation between serum adiponectin level and several parameters, such as interleukin (IL)-6, tumor necrosis factor (TNF)-α, lipid profile, and C reactive protein (CRP), and to clarify the association between adiponectin and cardiac function.
: Twenty-two KD patients (22 patients in acute phase and 20 patients in subacute phase) were enrolled in the study group. The control group consisted of 31 subjects (13 febrile patients and 18 healthy children). Both groups underwent blood sampling and tissue Doppler imaging (TDI).
: CRP was significantly increased in the KD group compared with the control group. There were no significant differences in serum TNF-α, IL-6, and adiponectin levels between groups. However, a negative correlation was found between adiponectin level and CRP level or platelet count. Systolic myocardial velocity and A myocardial velocity measured by TDI were decreased significantly in the acute KD group compared with the subacute KD group and control group. Positive correlations were found between adiponectin level and systolic myocardial velocity or A myocardial velocity.
: In acute KD patients, low adiponectin level was related to severe inflammatory reactions and decreased left ventricular functions.
Key Words: Kawasaki disease, Adiponectin, Echocardiography

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