| The effects of 1800 vGy cranial irradiation on intellectual function of children with acute lymphocytic leukemia. |
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Soo Ho Ahn1, Jeong Ok Hah1, Jung Hoon Lee2 |
1Department of Pediatrics, College of Medicine, Yeungnam University, Daegu, Korea
2Department of Psychiatry, College of Medicine, Yeungnam University, Daegu, Korea |
| 1800 cGy의 두개 방사선 조사가 급성 임파구성 백혈병
환아의 지능에 미치는 영향 |
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안수호1, 하정옥1, 이중훈2 |
1영남대학교 의과대학 소아과학교실
2영남대학교 의과대학 정신과학교실 |
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Received: 9 May 1991 • Accepted: 31 August 1991 |
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| Abstract |
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This study was conducted to investigate the effects of CNS prophylaxis with 1800 cGy cranial
irradiation and intrathecal methotrexate (MTX) chemotherapy on intellectual function of the chil-
dren with acute lymphocytic leukemia (ALL).
Thirteen longterm survivors with ALL who were treated with 1800 cGy cranial irradiation and
intrathecal MTX for CNS prophylaxis at pediatric department of Yeungnam University Hospital
from May, 1983 to November, 1988 were studied.
The Korean Wechsler Intelligence Scale for Children were administered to these patients and to a
sample of their healthy siblings, who served as a control group.
The mean Full Scale IQ was 100.8 for the patients and 100.5 for the sibling controls.
The mean Verbal Scale IQ was 98.0 for the patients, 99.1 for the sibling controls and the mean
Performance Scale IQ was 103.2 for the patients, 102.0 for the sibling controls. These data suggest
that CNS prophylaxis with 1800 cGy cranial irradiation and intrathecal MTX chemotherapy on
intellectual fuction as compared to 2400 cGy cranial irradiation, have no significant deleterious effect
on the intellectual function of the children with ALL.
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| Key Words:
Cranial irradiation, Intellectual function Acute lymphocytic leukemia, CNS prophylaxis, Intrachecal methotrexate |
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