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Clinical analysis on newborn infants treated with mechanical ventilation.

Journal of the Korean Pediatric Society 1991;34(10):1346-1355.
Published online October 31, 1991.
Clinical analysis on newborn infants treated with mechanical ventilation.
Yeon Sim Kim, Dae Ho Choi, Cheol Woo Park, Yeon Kyun Oh
Department of Pediatrics, College of Medicine, Won-Kwang University, Iri, Korea
호흡집중 치료를 시행한 신생아의 임상적 고찰
김연심, 최대호, 박철우, 오연균
원광대학교 의과대학 소아과학교실
Received: 4 March 1991   • Accepted: 13 May 1991
Clinical analysis of 48 neonates who treated with Mechanical ventilation in NICU at Won-Kwang University Hospital from February 1987 to July 1990 was performed. The results were as follows; 1) According to diagnostic categories, hyaline membrane disease was the most common in 26 cases (54.2%), and then postasphyxia syndrome 10cases (20.8%), apnea of prematurity 3cases (6.2%), sepsis 3 cases (6.2%),in their order. 2) 29 cases (60.4%) were bom at WUH and others were bom elesewhere, and male to female ratio was about 1.4:1. 3) Premature infants below 37 wks of gestational age were 32 cases (66.7%), and hyaline membrane disease were premature in 25 cases (96.2%). 4) Low birth weight infants below 2,500 gm were 36 cases(75%) and very low virth weight infants below 1,500gm were 14cases (29.2%). In 26 cases of hyaline membrane disease, infants below 2,500 gm were alll and below 1,500gm were 11 cases (42.3%). 5) According to selected mode of mechanical ventilation, CPAP mode was used in 7 cases (14.6%) and IPPB in 41 cases (85.4%). Assist ventilation was initiated before 24 hrs of age in 44 cases (91.7%) and in total duration of mechanical ventilation, 36 cases (75.0%) were below 3 days and 5 cases (10. 4%) above 7 days. 6) Complications were seen during mechnaical ventilation were infection (20.8%) including sepsis and pneumonia, extrapulmonary air leaks (14.6%), intracranial hemorrhage (12.5%), in their order. 7) Total survival rate was 35.4%. For each diagnostic categories, the survival rate in hyaline membrane disease was 30.8%, postasphyxia syndrome 30% and apnea of prematurity 100%. The survival rate in infants less than 999 gm was 0%, 1,000〜 1,499 gm 60%, 1,500—1,999 gm 41.7% and more than 2,500 gm 27.3%, and in infants of gestational age below 28 wks was 12.5%, 29〜3 wks 50%, 33-36 wks 20%. 8) Follow up observations were performed in 17 survived infants for the period of 3 months to 3 years and long term sequalaes were observed in 5cases (29.4%) as spastic quadriplegia, seizure disorder, bronchopulmonary dysplasia, delayed development and retinopathy of prematurity.
Key Words: Mechanical ventilation, Neonate

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