| Effect of yeast-derived methionyl recombinant growth hormone on growth hormone deficient dwarf. |
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Jong Jin Seo |
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Department of Pediatrics, Chungnam National University, College of Medicine, Daejon, Korea |
| 효모 추출 유전자 재조합 성장 호르몬의 성장호르몬
결핍성 왜소증에 대한 치료 효과 |
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서종진 |
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충남대학교 의과대학 소아과학교실 |
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Received: 31 March 1991 • Accepted: 10 April 1991 |
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| Abstract |
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Fifteen GH deficient dwarfs were treated with LBD-003, the first year-derived rhGH produced in
Korea.
The growth promoting effect of LBD-003 was excellent and similar to that of the pituitary extract
GH or the previous imported rhGHs.
The serum concentrations of IGF-1 at 6th and 12th month of treatment showed significant elevation
(p< 0.005, p< 0.001 respectively), but no significant correlation was observed between the concentra-
tions of IGF-1 and growth velocities.
The incidence of anti-GH antibody formation was similar to that of the previous methionyl rhGHs.
The growth-attenuating effect of the anti-GH antibody or significant side effect was not observed
during the GH treatment for 1 year. |
| Key Words:
Dwardism, Growth hormone deficiency, Growth hormone therapy, Methionyl recombinant human growth hormone |
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