| Surfactant replacement therapy in neonatal respiratory distress syndrome. |
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Chan Ok Park, Boung Yul Lim, Byeong Gie Yeo, Ji Ho Song, Eun Kyung Sohn, Chong Woo Bae, Sa Jun Chung, Chang Il Ahn |
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Department of Pediatrics, College of Medicine, Kyung Hee University, Seoul, Korea |
| 신생 아 Respiratory Distress Syndrome에서
Surfactant 보충 요법
- 치료군과 대조군의 임상적 비교 관찰 - |
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박찬옥, 임병열, 여병기, 송지호, 손은경, 배종우, 정사준, 안창일 |
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경희대학교 의과대학 소아과학교실 |
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Received: 20 March 1991 • Accepted: 22 May 1991 |
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| Abstract |
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Respiratory distress syndrome (RDS) in tiny infants remains a major medical challenge as they are
less tolerant of supportive care.
In 1959, after identification of the pulmonary surfactant (S), S replacement therapy were used to
treat RDS. This idea was first successfully tested on RDS infants by Fujiwara, et. al” in 1980. Now
the trial and use of S for the treatment in RDS is also popular in other countries.
We conducted a clinical trial of reconstitued bovine S(S-TA) comparing its efficacy in RDS.
S-treated group of 6 neonates and control group of 8 neonates were involved this study.
The results were as follows;
1) During the replacement of S through the endotracheal tube, hypoxia or hypercarbia were not
noticed, and a dramatic elevation of PaO2 appeared.
2) After replacement of S, there were significantly improved oxygenation (increased arterial-
alveolar O2 ratio) and chest roentgenographic findings, with decreased mean airway pressure and a
fraction of inspired oxygen in the S-treated group, unlike the control group.
3) Infants in the S-treated group had a more beneficial effect in the shortening of the duration of
oxygenation, mechanical ventilator care and timing of extubation of the endotracheal tube.
4) Infants in the S-treated group had less mortality and late complications than the infants in the
control group.
In conclusion, exogenous S replacement produced exellent results, which decreased pressure,
oxygen concentration and improved chest X-ray findings during ventilator care in the acute stage.
Also, there were decreased incidence of pulmonary and/or other complications during the late stage.
So, S replacement will become a important advance in the care of preterm infants with severe RDS. |
| Key Words:
Neonatal Respiratory Distress Syndrome, Surfactant Replacement |
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