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A clinical study on neonatal seizures.

Journal of the Korean Pediatric Society 1991;34(2):230-239.
Published online February 28, 1991.
A clinical study on neonatal seizures.
Bong Sik Kong, Ri Sa Lee, Sang Kyu Park, Ho Jin Park
Department of Pediatrics, Seoul Red Cross Hospital, Seoul, Korea
신생아 경련의 임상적 고찰
공봉식, 이리사, 박상규, 박호진
서울적십자병원 소아과
Received: 12 July 1990   • Accepted: 17 October 1990
Clinical observation were made on 57 cases of neonatal seizure who were admitted to the Depart- ment of pediatrics, Seoul Red Cross Hospital during the period of 7 years from Jan. 1983 to Dec. 1989. The results were as follows: 1) According to the type of delivery of neonates which showed neonatal seizure, normal vaginal delivery were 41 cases (71.9%), C-section delivary 11 cases (19.3%) and breech delivery were 5 cases (8.8%). 2) According to the gestational period, the frequency of preterm baby was 19.3% and of postterm baby was 5.3% and the majority of neonates were included to the term baby. 3) The most frequent cause of neonatal seizure was hypoxic-ischemic brain damage (36.8%), and followed by sepsis with or without meningitis (22.8%), intracranial hemorrhage (14%), hypoglycemia (5.3%), hyponatremia (5.3%) and kemicterus (3.5%) in order of frequency. 4) The onset of 12 cases (21%) of neonatal seizure appeared within 24hours of life, 11 cases (19.3%) in 2nd day and 5 cases (8.8%) in 3rd day. Two-third of neonatal seizure occurred within 7days of life. 5) The most frequent type of neonatal seizure was generalized tonic (54.4%) and followed by subtle (36.8%), multifocal clonic (5.3%) and myoclonic (3.5%) in order of frequency. 6) The brain CT were performed in 10 cases. They showed intracranial hemorrhage in 3 cases, frontal edema in 2 cases, massive hydrocephalus and ventriculitis, subdural hygroma in 1 case and there were no evidence of abnormality in 3 cases. 7) The result of EEG finding was normal (47.1%) and abnormal (52.9%). 8) As the result of treatment, 32 cases (56%) of neonatal seizure were discharge in the state of improvement, 19 cases (33.3%) were discharged against medical advice and 6 cases (10.5%) expired. 9) The most favorable outcome resulted from neonate with medical disturbance (improved in all cases) and the worst outcome resulted from neonate with intracranial hemorrhage (improved in 25%).
Key Words: Neonatal seizures

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