| HLA Typing, Islet Cell Antibody and C-Peptide of Insulin Dependent Diabetes Mellitus in Children. |
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Hyeong Rae Cho1, Sei Joong Ko1, Duk Hi Kim1, Hyun Chul Lee2, Kap Bum Huh2 |
1Department of Pediatrics, Yonsei University, College of Medicine, Seoul, Korea
2Department of Internal Medicine, Yonsei University, College of Medicine, Seoul, Korea |
| 인슐린 의존형 당뇨병 환아의 HLA Typing, Islet Cell
Antibody 및 C-Peptide의 변화에 관한 연구 |
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조형래1, 고세중1, 김덕희1, 이현철2, 허갑범2 |
1연세대학교 의과대학 소아과학교실
2연세대학교 의과대학 내과학교실 |
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Received: 13 August 1990 • Accepted: 10 September 1990 |
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| Abstract |
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35 childhood insulin-dependent (Typel) diabetes mellitus were typed for HLA and examined for
presence of islet cell antibody and level of C-peptide. The following results were obtained:
1) HLA types were present as follows; HLA A24 (9) in 58%, DR3 in 38% and DR4 in 62%. This was
slightly higher than the Korean population of 38%, 7% and 48% but there was no significant
difference.
2) When islet cell cytoplasmic antibody (ICA) and islet cell surface antibody (ICSA) were studied
in 18 cases, ICA was positive in 22% and ICSA in 17%. All the ICSA positive cases were examined
within 1 month after onset of the disease.
3) The C-peptide level in accordance with duration of the disease was similar to that of disease
onset for a year after onset of the disease. However it was decreased after 2 years onset of the disease.
These finding was independent of HLA types. And in groups receiving cyclosporin A it was noted that
C-peptide level was significantly increased at 3 months after onset of the disease as compared to the
group not receiving cyclosporin A but C-peptide level was decreased in both groups 2 years after onset
of the disease. |
| Key Words:
Childhood insulin-dependent (Typel) diabetes mellitus |
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