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The Effects of Cyclosporin in Treatment of Insulin Dependent Diabetes Mellitus.

Journal of the Korean Pediatric Society 1985;28(6):564-569.
Published online June 30, 1985.
The Effects of Cyclosporin in Treatment of Insulin Dependent Diabetes Mellitus.
Duk Hi Kim
Dept, of Pediatrics, Yonsei Univ. College of Med.
인슈린의존형 당뇨병 환아에 대한 Cyclosporin투여 효과
연세의대 소아과
A 2 year 10 month old girl with 6 weeks duration and 13 year 4 month old boy with 8 weeks duration were given cyclosporin for 68 days. Therapy was initiated orally at the dosage of 10 mg per kg of body per day. Blood glucose, C-peptide, cyclosporin, creatinin, BUN and transaminase were checked regularly. Cyclosporin treatment allowed two patients to reduce their insulin dosage by 80% or more and fasting C-peptide level had increased from 0.52 to 1.32 ng/ml and 0.87 to 1.8 ng/ml respectively. At 68 days After cyclosporin treatment, glucagon tests were done and C-peptide levels increased with glucose levels. They didn’t have any hepatotoxicity or nephrotoxicity but have minor side reaction including mild loss of hair in scalp and hirsutism around eyebrows. I suggest that cyclosporin seems to be apparent benificial effect in type I diabetes mellitus and those results call for further study in a controlled clinical trials.
Key Words: Cyclosporin, C-peptide, Insulin dependent diabetes mellitus

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