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The Effect of Pertussive Vaccine & Cyclosporin on Streptozotocin Induced Diabetic Rats.

Journal of the Korean Pediatric Society 1988;31(7):914-923.
Published online July 31, 1988.
The Effect of Pertussive Vaccine & Cyclosporin on Streptozotocin Induced Diabetic Rats.
Duk Hi Kim
Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea
백일해 백신 및 사이크로스포린 투여가 streptozotocin 유발성 당뇨쥐에 미치는 영향
김덕희
연세대학교 의과대학 소아과학교실
Received: 27 January 1988   • Accepted: 27 January 1988
Abstract
The injection of streptozotocin (STZ) at higher dose (60 mg/kg) to young male rats produce direct beta cell destruction and lead to insulin dependent diabetes (IDD). In contrast, the injection of multiple smaller dose of STZ (40 mg/kg/d for 5 days) produce IDD, which resembles type 1 diabetes in man. The protective effect of pertussis vaccine (PV) & cyclosporin (CA) against the develoment of IDD induced by STZ were studied. When PV with a dose of 0.25 ml (3.75 x IO10 microorganism) was administered to single or multiple STZ treated rats, hyperglycemia was still developed and persisted during experiment. No difference was noted in blood glucose levels, but plasma insulin levels were higher at 8 weeks in single and 3 days, 7 days & 4 weeks in multiple STZ treated rats. When CA (10 mg/kg) was administered daily to single or multiple STZ treated rats, hyperglycemia seemed to lower but there was no statistically significant, but plasma insulin levels were higher at 3 days & 7 days in single and 8 weeks in multiple STZ treated rats. The resluts of this experiment suggest PV and CA can somewhat protect beta cell of pancreas but they couldn’t reduced nonfasting blood glucose levels significantly.
Key Words: pertussis vaccine, cyclosporin, streptozotocin, insulin dependent diabetes mellitus.


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