| The Effect of Pertussive Vaccine & Cyclosporin on Streptozotocin Induced Diabetic Rats. |
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Duk Hi Kim |
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Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea |
| 백일해 백신 및 사이크로스포린 투여가 streptozotocin
유발성 당뇨쥐에 미치는 영향 |
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김덕희 |
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연세대학교 의과대학 소아과학교실 |
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Received: 27 January 1988 • Accepted: 27 January 1988 |
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| Abstract |
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The injection of streptozotocin (STZ) at higher dose (60 mg/kg) to young male rats produce direct
beta cell destruction and lead to insulin dependent diabetes (IDD). In contrast, the injection of multiple
smaller dose of STZ (40 mg/kg/d for 5 days) produce IDD, which resembles type 1 diabetes in man.
The protective effect of pertussis vaccine (PV) & cyclosporin (CA) against the develoment of IDD
induced by STZ were studied. When PV with a dose of 0.25 ml (3.75 x IO10 microorganism) was
administered to single or multiple STZ treated rats, hyperglycemia was still developed and persisted
during experiment. No difference was noted in blood glucose levels, but plasma insulin levels were
higher at 8 weeks in single and 3 days, 7 days & 4 weeks in multiple STZ treated rats.
When CA (10 mg/kg) was administered daily to single or multiple STZ treated rats, hyperglycemia
seemed to lower but there was no statistically significant, but plasma insulin levels were higher at 3
days & 7 days in single and 8 weeks in multiple STZ treated rats.
The resluts of this experiment suggest PV and CA can somewhat protect beta cell of pancreas but
they couldn’t reduced nonfasting blood glucose levels significantly. |
| Key Words:
pertussis vaccine, cyclosporin, streptozotocin, insulin dependent diabetes mellitus. |
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