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The effect of pertussis vaccine on streptozotocin induced diabetic rats.

Journal of the Korean Pediatric Society 1991;34(7):897-906.
Published online July 31, 1991.
The effect of pertussis vaccine on streptozotocin induced diabetic rats.
Kyung Rae Moon1, Kwang Rhun Koo1, Sang Kee Park1, Yeong Bong Park1, Byoung Rai Lee2, Keun Hong Kee3
1Department of Pediatrics, College of Medicine, Chosun University, Kwangju, Korea
2Department of Biochemistry, College of Medicine, Chosun University, Kwangju, Korea
3Department of Pathology, College of Medicine, Chosun University, Kwangju, Korea
백일해 백신이 streptozotocin 유발성 당뇨백서에 미치는 영향(제 1보)
문경래1, 구광련1, 박상기1, 박영봉1, 이병래2, 기근흥3
1조선대학교 의과대학 소아과학교실
2조선대학교 의과대학 생화학교실
3조선대학교 의과대학 병리학교실
Received: 3 April 1991   • Accepted: 31 May 1991
Abstract
Streptozotocin produces diabetes in laboratory animals through the destuction of the pancreatic beta cells. The diabetogenic activity of STZ, however, is known to be modified by several agents such as nicotinamide, diazoxide, adrenergic blockers and petussis vaccine (PV). The present study was undertaken to observe the protective effect of PV or boiled pertussis vaccine (bPV; incubating the PV at 80 C for 30 mintues) against the development of insulin dependent diabetes induced by STZ in young rats, and also the effect of PV on the activites of glucokinase & glucose 6-phosphatase in the liver. PV at a dose of 1.2xIO10 miroorganism was administrated on 3days before & 7 days after a single injection of STZ (60 mg/kg body wt). The blood glucose and insulin levels were measured at 1st, 2nd, 4wks, 6th and 8th wks after STZ injection, and the activities of glucokinase & glucose 6-phosphatase and the histological examination were studied at 8th wk after STZ 1 injection. The following results were obtained. 1) No significant difference was noted in blood glucose levels between STZ group and STZ+PV or STZ+bPV groups (p>0.05). 2) Blood insulin levels in STZ group decreased significantly from 2nd wk (p < 0.05). Compared with STZ group, blood insulin levels in STZ + PV & STZ+bPV groups were higher, not a significant value except at 2nd wk in STZ + PV group(p>0.05). 3) No significant difference was noted in the activities of hepatic glucokinase & glucose-6 phos- phatase between STZ group and STZ + PV or STZ+bPV group(p>0.05). 4) On microscopically, a destruction of Langerhan’s islet and its cells in STZ + PV and STZ+bPV groups was less remarkable than that in STZ group. These results suggest that the PV has somewhat protective effects on islet cell of pancreas in rats but it could not reduced blood glucose levels significantly.
Key Words: Streptozotocin, Pertussis vaccine, Diabetes


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