| The effect of dietary fats of immune response in sublethally irradiated rats. |
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Soon Hwan Oh1, Dong Soo Kim1, Hae Won Nam2, Juhn Kyu Loh3 |
1Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea
2Department of Food and Nutrition The Graduate School Yonsei University, Seoul, Korea
3Department of Radiotherapy, Yonsei University College of Medicine, Seoul, Korea |
| 방사선 조사를 받은 백서에서 식이지질이 면역능력
회복에 미치는 영향 (II) |
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오순환1, 김동수1, 남혜원2, 노준규3 |
1연세대학교 의과대학 소아과학교실
2연세대학교 생활과학대학 식생활과
3연세대학교 치료방사선과학교실 |
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Received: 22 March 1991 • Accepted: 7 June 1991 |
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| Abstract |
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To investigate the effect of dietary fats on cellular immune response in the immunosuppressed rats,
different compositions in the quality and quantity of dietary fats were fed to sublethally irradiated
male rats.
The results are as follows;
1) After 2 weeks of irradiation, the mean body weight of the fat free dietary group was significant-
ly lower than the com oil group. The organ weight, especially the liver weight, had increased after
irradiation.
2) After irradiation, except the com oil group, the triglyceride content increased especially in the
beef tallow group. The cholesterol level after irradiatin, com oil group was significantly lower than
in the other groups.
3) The stimulation index of the spleen cells by PHA after irradiation was lower in all groups than
that of not irradiated groups. After irradiation, the com oil group was the lowest of all the other
groups indicating the immunosuppressive effect of 切-6 fatty acid.
4) After irradiation, NK cell activity increased significantly in all groups, and the perilla oil group
was the highest than any other group, indicating the a)-3 fatty acid might increase immune response.
5) One day after whole body irradiation, histology of bone marrow and thymus showed radiation
effect, but it was recovered to almost normal 2 weeks after irradiation. On the other hand, liver
revealed a minimal change one day after irradiation, but a marked degree of cell death 2 weeks after
irradiation.
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| Key Words:
Dietary fat, Immunity, Radiotherapy |
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