| Selectivity Index of Proteinuria in Childhood Minimal Change Nephrotic Syndrome. |
|
Cheol Ho Lee, Young Seo Park, Kwang Wook Ko |
|
Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea |
| 소아 미세변화 신증후군에서의 단백뇨 선택지수에 관한 연구 |
|
이철호, 박영서, 고광욱 |
|
서울대학교 의과대학 소아과학교실 |
|
Received: 6 March 1989 • Accepted: 11 May 1989 |
|
|
| Abstract |
|
The selectivity indices (S.I.) of proteinuria in 120 biopsy proven minimal change nephrotic syn-
drome (MCNS) children who were admitted to Seoul National University Childern’s Hospital from
January 1976 to June 1988 and followed up for more than 1 year from onset of disease, were analyzed
in relation to clinical findings, histopathologic features and steroid responsiveness.
The results were as follows:
1) The mean age at the onset of nephrotic syndrome was 6.98 ±3.58 years and the male to female
ratio was 3.14:1.
2) All patients were classified into 3 groups according to S.I.; 51 cases (42.5%) with high S.I. (^0.
1), 29 cases (24.2%) with moderate S.I.(>0.1—<0.2) and 40 cases (33.3%) with poor S.I.(>0.2).
3) Mean age of onset, sex ratio and presence of nephritic findings such as hematuria, hypertension
and renal insufficiency revealed no significant difference among the 3 groups with different S.I..
4) No significant difference in the distribution of histopathologic variants was noted among the 3
groups either.
5) Initial response to steroid therapy and frequency of relapse were not different among the 3
groups, however, subsequent nonresponders and continuing nonresponders were more frequent in
those with poor S.I. than in those with high S.I. during later follow up (p<0.05).
In conclusion, S.I. of proteinuria in childhood MCNS can be used as a predictive indicator for late
response to steroid therapy. |
| Key Words:
Minimal change nephrotic syndrome, Selectivity index |
|
PDF Links
Download Citation
