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Selectivity Index of Proteinuria in Childhood Minimal Change Nephrotic Syndrome.

Journal of the Korean Pediatric Society 1989;32(10):1384-1390.
Published online October 31, 1989.
Selectivity Index of Proteinuria in Childhood Minimal Change Nephrotic Syndrome.
Cheol Ho Lee, Young Seo Park, Kwang Wook Ko
Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea
소아 미세변화 신증후군에서의 단백뇨 선택지수에 관한 연구
이철호, 박영서, 고광욱
서울대학교 의과대학 소아과학교실
Received: 6 March 1989   • Accepted: 11 May 1989
The selectivity indices (S.I.) of proteinuria in 120 biopsy proven minimal change nephrotic syn- drome (MCNS) children who were admitted to Seoul National University Childern’s Hospital from January 1976 to June 1988 and followed up for more than 1 year from onset of disease, were analyzed in relation to clinical findings, histopathologic features and steroid responsiveness. The results were as follows: 1) The mean age at the onset of nephrotic syndrome was 6.98 ±3.58 years and the male to female ratio was 3.14:1. 2) All patients were classified into 3 groups according to S.I.; 51 cases (42.5%) with high S.I. (^0. 1), 29 cases (24.2%) with moderate S.I.(>0.1—<0.2) and 40 cases (33.3%) with poor S.I.(>0.2). 3) Mean age of onset, sex ratio and presence of nephritic findings such as hematuria, hypertension and renal insufficiency revealed no significant difference among the 3 groups with different S.I.. 4) No significant difference in the distribution of histopathologic variants was noted among the 3 groups either. 5) Initial response to steroid therapy and frequency of relapse were not different among the 3 groups, however, subsequent nonresponders and continuing nonresponders were more frequent in those with poor S.I. than in those with high S.I. during later follow up (p<0.05). In conclusion, S.I. of proteinuria in childhood MCNS can be used as a predictive indicator for late response to steroid therapy.
Key Words: Minimal change nephrotic syndrome, Selectivity index

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