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Colonization Factor Antigens of Heat-stable Enterotoxin-Producing (STf) E. Coli in Korean Children.

Journal of the Korean Pediatric Society 1989;32(9):1210-1215.
Published online September 30, 1989.
Colonization Factor Antigens of Heat-stable Enterotoxin-Producing (STf) E. Coli in Korean Children.
Kon Hee Lee1, Kyung Hee Kim2, Yang Ja Cho2
1Department of Pediatrics, Hallyn University College of Medicine, Seoul, Korea
2Department of Microbiology, Hanyang University College of Medicine, Seoul, Korea
한국 소아에서의 내열성 장독소 산생대장균의 Colonization Factor Antigens
이건희1, 김경희2, 조양자2
1한림대학교 의과대학 소아과학교실
2한양대학교 의과대학 미생물학교실
Received: 27 February 1989   • Accepted: 24 April 1989
Enterotoxigenic Escherichia coli (ETEC) cause an acute cholera-like diarrhea in both human and animals. The disease process involves colonization of the mucosal surfaces of the small intestine followed by elaboration of ST and/or heat-labile enterotoxin (LT). Intestinal colonization by ETEC is mediated by specific surface-associated fimbrial or fibrillar antigens including colonization factor antigens (CFA) I and II. Isolates of E. coli from 114 children with diarrhea admitted to and 58 healthy children seen at the well baby clinic of Hanyang University Hospital in Seoul, Korea, were examinied for possesion of the CFA I and/or II with mannose-resistant^ hemagglutination and immunodiffusion assay. CFA I and CFA II expressing (CFA I+/CFA II+) E. coli were isolated from 11% and 4% of the diarrheal children, and from 2% and 2% of the healthy control (CFA I; P<0.05). CFAs were expressed only in ST+ E. coli. This finding confirms several earlier studies that CFAs are restricted to ETEC. Of the 41 ST+ strains, 20% carried the CFA I and 11% possessed the CFA II. The CFA I was restricted to E. coli serotype 025 and the CFA II was found on serotypes 025 and 020a020b. A continuous search for other attachment factors are needed to give a sound basis for a multivalent vaccine against ST-associated diarrhea.
Key Words: Colonization factor antigens

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