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Serum LDH and Isoenzyme Activity in Children with Respiratory Diseases.

Journal of the Korean Pediatric Society 1989;32(8):1051-1056.
Published online August 31, 1989.
Serum LDH and Isoenzyme Activity in Children with Respiratory Diseases.
Kyoung Min Ann, Young Kyoo Shin, Kwang Chul Lee, Ji Tae Choung, Young Chang Tockgo, Pyung Hwa Choe
Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea
소아 호흡기질환에서의 혈청 Lactic Dehydrogenase 및 Isoenzyme의 변화
안경민, 신영규, 이광철, 정지태, 독고영창, 최평화
고려대학교 의과대학 소아과학교실
Received: 10 July 1989   • Accepted: 10 July 1989
Abstract
LDH which are widely distributed in mammalian tissues, being rich in myocardium, kidney, liver and muscle, and which is well known to catalyzes the reversible oxidation of lactate to pyruvate. We investigated serum LDH & Isoenzyme changes in 317 cases of children with respiratory disease and in 117 cases of healthy children as control. The objectives of this study were to ascertain whether serum LDH changes with respiratory diseases. The results obtained were as follows. 1) The average serum LDH levels are 383 ±68 U/ml and showed decreasing tendency by age as follows: 571±91 U/ml in under one year old age group, 560±125 U/ml in 1 year, 429±107 U/ml in 2 year, 473 ±58 U/ml in 3 year, 444 ±84 U/ml in 4 year, 453 ±87 U/ml in 5 year, 458 ±95 U/ml in 6 year, 398±29 U/ml in 7 year, 361 ±51 U/ml in 8 year, 376+71 U/ml in 9 year, 393±88 U/ml in 10 year, 375± 45 U/ml in 11 year, 352±39 U/ml in 12 year and 310±52 U/ml in above 13 year respectively. 2) The average serum LDH levels in respiratory disease also showed decreasing tendency by age significantly (R<0.5). 3) Serum LDH levels are increased in pneumonia, especially in interstitial type than lobar type but there were no statistical difference between bronchitis, bronchiolitis, asthma and control. 4) Isoenzyme of LDH in pneumonia resulted slight increase in L2, L3 without statistical signifi- cance.
Key Words: Lactic Dehydrogenase, Isoenzyme, Respiratory Disease


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