| Serum IgE Level in Patients with Minimal Change Nephrotic Syndrome. |
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Sung Oh Kim, Hee Jung Ahn, Seong Ho Kim, Woo Gill Lee |
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Department of Pediatrics, Hanyang University College of Medicine, Seoul, Korea |
| 신증후군 환아에서 혈청 IgE치의 임상적 의의 |
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김성오, 안희정, 김성호, 이우길 |
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한양대학교 의과대학 소아과학교실 |
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Received: 28 November 1988 • Accepted: 28 November 1988 |
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| Abstract |
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It has been reported that many patients with minimal change nephrotic syndrome(MCNS) have
high serum IgE level, but its significance has not been disclosed yet. In this study, serum levels of IgE
were evaluated in different stages of the disease with or without treatment in 26 MCNS(proven by
renal biopsy) patients admitted to the Department of Pediatrics Hanyang University Hospital from
January, 1980 to April, 1988. The study showed higher serum levels of IgE in patients with MCNS than
control.
In comparison of serum IgE levels according to age group in nephrotic phase(regardless of initial
attack or relapse) and in remission phase of MCNS, IgE levels were increased in all the age groups
of nephrotic phase than control, and in remission phase IgE was increased in age groups of 1-5 year
and of 6-9 year. No significant increase in age group over 10 year was noted In male patients, serum
IgE levels of nephrotic phase and of remission phase, were higher than control, but in female, only
nephrotic phase they were higher than control. There was significant difference between IgE levels
during the nephrotic phase and remission phase of the disease. Steroid responders had higher serum
levels of IgE than non-responders and dependents.
In conclusion, it may be possible that serum IgE levels can be used as a predictive value for the
clinical course of MCNS patients. However, because of variable serum IgE levels during follow-up
studies, continuing studies of patients with MCNS will be necessary to clarify its significance of
change in serum IgE levels. |
| Key Words:
Serum IgE, Minimal change nephrotic syndrome |
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