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Serum IgE Level in Patients with Minimal Change Nephrotic Syndrome.

Journal of the Korean Pediatric Society 1989;32(6):789-796.
Published online June 30, 1989.
Serum IgE Level in Patients with Minimal Change Nephrotic Syndrome.
Sung Oh Kim, Hee Jung Ahn, Seong Ho Kim, Woo Gill Lee
Department of Pediatrics, Hanyang University College of Medicine, Seoul, Korea
신증후군 환아에서 혈청 IgE치의 임상적 의의
김성오, 안희정, 김성호, 이우길
한양대학교 의과대학 소아과학교실
Received: 28 November 1988   • Accepted: 28 November 1988
It has been reported that many patients with minimal change nephrotic syndrome(MCNS) have high serum IgE level, but its significance has not been disclosed yet. In this study, serum levels of IgE were evaluated in different stages of the disease with or without treatment in 26 MCNS(proven by renal biopsy) patients admitted to the Department of Pediatrics Hanyang University Hospital from January, 1980 to April, 1988. The study showed higher serum levels of IgE in patients with MCNS than control. In comparison of serum IgE levels according to age group in nephrotic phase(regardless of initial attack or relapse) and in remission phase of MCNS, IgE levels were increased in all the age groups of nephrotic phase than control, and in remission phase IgE was increased in age groups of 1-5 year and of 6-9 year. No significant increase in age group over 10 year was noted In male patients, serum IgE levels of nephrotic phase and of remission phase, were higher than control, but in female, only nephrotic phase they were higher than control. There was significant difference between IgE levels during the nephrotic phase and remission phase of the disease. Steroid responders had higher serum levels of IgE than non-responders and dependents. In conclusion, it may be possible that serum IgE levels can be used as a predictive value for the clinical course of MCNS patients. However, because of variable serum IgE levels during follow-up studies, continuing studies of patients with MCNS will be necessary to clarify its significance of change in serum IgE levels.
Key Words: Serum IgE, Minimal change nephrotic syndrome

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