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A Clinical Observation of the Nephrotic Syndrome

Journal of the Korean Pediatric Society 1973;16(3):212-218.
Published online March 31, 1973.
A Clinical Observation of the Nephrotic Syndrome
Hwa Woong Chung, Soo Ja Kim, Pyung Kil Kim, Duk Jin Yun
Department of Pediatrics, Yonsei University College of Medicine Seoul, Korea
腎症候群의 臨床的 觀察 - 免疫抑制劑의 效果에 對하여
鄭和雄, 金秀子, 金炳吉, 尹德鎭
延世大學校 醫科大學 小兒科學敎室
A clinical observation was made on 81 cases of idiopathic nephrotic syndrome occurring under the age of 15 out of 11,850 admissions to the Department of Pediatrics at Severance Hospital, Yonsei University, from May, 1956 to April, 1972. The incidence of the nephrotic syndrome in children compries 0.7% of the total admission cases: The age, sex of the patients, clinical symptoms and signs, laboratory findings, especially relationship of blood chemistry and urine protein, and effects of steroid and immunosuppressive drug therapy were analyzed and data were summarized as follows: 1.The age distribution o£ 81 cases showed the highest incidence at the ages of 6~ 10 years(55. 6%) and none was under the 1 year of age. 2.The sex ratio of male and female was pproximatery 3 : 1. 3.As the initial manifestation, edema was the most common complaints(95.1%') and next were diminished urine output(59.3%), abdominal distension(51.9%), and anorexia(40.7%). 4.Concerning relationship between the urine protein and serum protein, between the urine protein and serum cholesterol, if proteinuria was massive ( - or -) serum protein level was low and serum cholesterol was high. 5.In general, steroid and immunosuppressive drug effect were good, but the treatment with steroid plus immunosuppressive drug was more effect than steroid only. 6.As the results of follow up at O.P.D., duration of follow up was most between 1 and 2 years, and recurrent cases was 68.7% in 1 year.

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