| Diagnosis of Meconium Aspiration by Spectrophotometric Analysis of Urine. |
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Chang Yul Kim, Hye Kyung Bae, Mee Kyung Namgoong, Baek Keun Lim, Joong Soo Kim |
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Department of Pediatrics, Wonju College of Medicine, Yonsei University, Wonju, Korea |
| 신생아 태변흡인 진단을 위한 요의 분광광도 분석 |
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김창열, 배혜경, 남궁미경, 임백근, 김종수 |
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연세대학교 원주의과대학 소아과학교실 |
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Received: 4 April 1988 • Accepted: 10 May 1988 |
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| Abstract |
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We measured optical density of aqueous extracts of meconium and meconium stained amniotic
fluid at 390 nm, 405 nm, 420 nm, 435 nm, 450 nm by spectrophotometry.
We also applied the spectrophotometric method to the urine from 25 infants with clinical sign of
meconium aspiration and from normal infants.
The absorption band at 450 nm observed on the spectra of urine was estimated as a Urinary
Meconial Index (UMI=[OD405-(OD390+OD420/2)] X50).
The results were as follows;
1) The absorption spectrum for a solution of meconium in water contains a peak at 405 nm.
2) A peak in the same position can be seen in urine from infants with meconium aspiration and in
samples of meconium-stained amniotic fluid, but not in normal urine.
3) There is a clear separation of Urinary Meconial Index between normal infants and infants with
meconium aspiration.
These results suggest that spectrophotometric analysis of the first urine can in this way be used to
diagnose preceding meconium aspiration. |
| Key Words:
Meconium aspiration syndrome, Urine, Urinary Meconial Index |
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