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Diagnosis of Meconium Aspiration by Spectrophotometric Analysis of Urine.

Journal of the Korean Pediatric Society 1988;31(10):1275-1280.
Published online October 31, 1988.
Diagnosis of Meconium Aspiration by Spectrophotometric Analysis of Urine.
Chang Yul Kim, Hye Kyung Bae, Mee Kyung Namgoong, Baek Keun Lim, Joong Soo Kim
Department of Pediatrics, Wonju College of Medicine, Yonsei University, Wonju, Korea
신생아 태변흡인 진단을 위한 요의 분광광도 분석
김창열, 배혜경, 남궁미경, 임백근, 김종수
연세대학교 원주의과대학 소아과학교실
Received: 4 April 1988   • Accepted: 10 May 1988
We measured optical density of aqueous extracts of meconium and meconium stained amniotic fluid at 390 nm, 405 nm, 420 nm, 435 nm, 450 nm by spectrophotometry. We also applied the spectrophotometric method to the urine from 25 infants with clinical sign of meconium aspiration and from normal infants. The absorption band at 450 nm observed on the spectra of urine was estimated as a Urinary Meconial Index (UMI=[OD405­­-(OD390+OD420/2)] X50). The results were as follows; 1) The absorption spectrum for a solution of meconium in water contains a peak at 405 nm. 2) A peak in the same position can be seen in urine from infants with meconium aspiration and in samples of meconium-stained amniotic fluid, but not in normal urine. 3) There is a clear separation of Urinary Meconial Index between normal infants and infants with meconium aspiration. These results suggest that spectrophotometric analysis of the first urine can in this way be used to diagnose preceding meconium aspiration.
Key Words: Meconium aspiration syndrome, Urine, Urinary Meconial Index

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