| Changes of Specific Immunogloblins Against Dihperia Toxoid After DPT Vaccination. |
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Byung Sook Park, Byung An Shim, Kyung Jin Shin, Soo Chul Cho, Jung Soo Kim |
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Department of Pediatrics, College of Medicine, Chonbuk National University, Jean Ju, Korea |
| DPT 예방접종에 따른 디프테리아
특이 면역글로불린의 변화 |
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박병숙, 심병안, 신경진, 조수철, 김정수 |
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전북대학교 의과대학 소아과학교실 |
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Received: 1 February 1988 • Accepted: 21 March 1988 |
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| Abstract |
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The present study was performed to define the humoral immune responses after DPT vaccination
changes of diphteria specific IgG and IgM were evaluated suing ELISA method on 196 cases of 6
groups which were divided according to the frequency of DPT vaccination.
Alum-precipitated diphtheria toxoid was used as antigen for ELISA.
The results were as follows;
1) IgG was mainly involed in humoral immune responses against diphtheria toxoid after DPT
vaccination.
2) At least 2 times of vaccination were required to obtain the significant increases of diphtheria
specific IgG titer. The values of diphtheria specific IgG were remained for about 2 years after
vaccination and decreased slowly thereafter.
3) The values of diphtheria specific IgG were similar in both primary (DPT 3 times) and booster
group (DPT 4 times) for 2 years vaccination, but significantly decreased in primary group after 2
years of vaccination.
4) The values of diphtheria specific IgG were relatively lower in neonates than adults.
These results suggest that the primary vaccination schedule in Korea seems to be reliable and
continuous booster vaccination on adults might be required. |
| Key Words:
DPT vaccination, Diphtheria specific immunoglobulin |
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