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Changes of Specific Immunogloblins Against Dihperia Toxoid After DPT Vaccination.

Journal of the Korean Pediatric Society 1988;31(9):1126-1132.
Published online September 30, 1988.
Changes of Specific Immunogloblins Against Dihperia Toxoid After DPT Vaccination.
Byung Sook Park, Byung An Shim, Kyung Jin Shin, Soo Chul Cho, Jung Soo Kim
Department of Pediatrics, College of Medicine, Chonbuk National University, Jean Ju, Korea
DPT 예방접종에 따른 디프테리아 특이 면역글로불린의 변화
박병숙, 심병안, 신경진, 조수철, 김정수
전북대학교 의과대학 소아과학교실
Received: 1 February 1988   • Accepted: 21 March 1988
Abstract
The present study was performed to define the humoral immune responses after DPT vaccination changes of diphteria specific IgG and IgM were evaluated suing ELISA method on 196 cases of 6 groups which were divided according to the frequency of DPT vaccination. Alum-precipitated diphtheria toxoid was used as antigen for ELISA. The results were as follows; 1) IgG was mainly involed in humoral immune responses against diphtheria toxoid after DPT vaccination. 2) At least 2 times of vaccination were required to obtain the significant increases of diphtheria specific IgG titer. The values of diphtheria specific IgG were remained for about 2 years after vaccination and decreased slowly thereafter. 3) The values of diphtheria specific IgG were similar in both primary (DPT 3 times) and booster group (DPT 4 times) for 2 years vaccination, but significantly decreased in primary group after 2 years of vaccination. 4) The values of diphtheria specific IgG were relatively lower in neonates than adults. These results suggest that the primary vaccination schedule in Korea seems to be reliable and continuous booster vaccination on adults might be required.
Key Words: DPT vaccination, Diphtheria specific immunoglobulin


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