| Quantitative Determination of Immunologlobulins in Breast Milk During the Period of Lactation. |
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Sung Ee Kim, Chang Soo Ra |
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Department of Pediatrics, College of Medicine, Chosun University |
| 모유내 면역글로부린의 양적측정 |
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김성의, 나창수 |
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조선대학교 의과대학 소아과학교실 |
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| Abstract |
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It has been established by many investigations that immunoglobulins in breast milk, par-
ticularly secretory IgA, are important in. protecting the infant, not only through the colostrum
but through milk from birth to the early months of life. In order to determine the levels
of immunoglobulins in breast milk and the alterations of levels of immunoglobulins during
the period of lactation, the authors studied the levels of main classes of immunoglobulins
in breast milk from the mothers, from 1st day to 30th day after childbirth, and from the
mothers who have breast-fed infant aged from 2 months to 12 months by the method of
immunodiffusion assay(IATRON immunodiffusion set, Japan).
The mean levels of i mmunoglobulins at 1st, 3rd, 5th, 7th and 30th day respectively were
as follows;
IgA: 2,117 mg/dl, 176 mg/dl, 157 mg/dl, 117 mg/dl and 66 mg/dl
IgM: 293 mg/dl, 42 mg/dl, 29 mg/dl, 29 mg/dl and 23 mg/dl
IgG: 44 mg/dl, 9 mg/dl, 12 mg/dl, 13 mg/dl and 11 mg/dl
The mean levels of immunoglobulins at 2nd, 4th, 6th, 8th, 10th and 12th. month respe-
ctively were as follows;
IgA: 66 mg/dl, 47 mg/dl, 70 mg/dl, 50 mg/dl, 60 mg/dl and 52 mg/dl
IgM: 37 mg/dl, 29 mg/dl, 34 mg/dl, 27 mg/dl, 26 mg/dl and 21 mg/dl
IgG: 12 mg/dl, 7 mg/dl, 11 mg/dl, 6 mg/dl, 9 mg/dl and 8 mg/dl
It was found that IgA immunoglobulin level was very high at 1st day postpartum, and
dropped precipitously in the first 3 to 5 days postpartum, and thereafter remained almost
constant for the rest period of lactation. In the case of IgM and Ig G, similar results were
observed, but the levels were much lower. Indi visual variations of levels of immunoglobulins
were found at different time after the onset of lactation.
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| Key Words:
Immunoglobulins, breast milk. |
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