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A Clinical Observation on the Incidence of Childhood Leukemia.

Journal of the Korean Pediatric Society 1988;31(7):841-849.
Published online July 31, 1988.
A Clinical Observation on the Incidence of Childhood Leukemia.
Hyo Seop Ahn, Il Soo Ha, Soon Ki Kim, Hoan Jong Lee, Chang Yee Hong
Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea
소아 백혈병의 빈도에 관한 관찰
안효섭, 하일수, 김순기, 이환종, 홍창의
서울대학교 의과대학 소아과학교실
Received: 9 June 1988   • Accepted: 9 June 1988
We have analysed the type, age, sex, initial hematologic values and cell markers in 295 children, who had been diagnosed as leukemia at the department of pediatrics, Seoul National University Hospital, from Jan. 1983 to Dec. 1987. The patients were composed of 197 cases (66.8%) of ALL, 82 cases (27.7%) of ANLL and 16 cases (5.5%) of CML. FAB subclassification have been done in acute leukemia; 76.7%, 19.3% and 1.5% of the ALL patients had FAB LI, L2 and L3 morphology, whereas 12.2%, 35.4%, 7.3%, 14.6%, 13.4%, 7.3% and 9.8% of the ANLL patients have been classified as FAB Ml, M2, M3, M4, M5, M6, and M7 respectively. In sixteen CML patients, seven had juvenile, nine had adult type. In ALL, a primary age peak lay before four year and a secondary peak around eleven year, while there was no marked age peak in ANLL. Sex ratio of the patients was 1.3: 1 in acute leukemia and 3: 1 in CML. Compared to ANLL, extreme leukemic leukocytosis was observed more frequently in ALL (p<0.05). Among the 136 cases of ALL, 69.9% were subgrouped as common ALL, 16.9% as T ALL, 11.0% as null ALL, 1.5% as pre-B ALL and 0.7% as B ALL, by expressed cell markers.
Key Words: Childhood leukemia, Incidence, FAB Classification, Immunologic Classification, Hematologic values

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