| Periperal Plasma Renin Activity in Children with Normotensive Reflux Nephropathy. |
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Chong Guk Lee, Kwang Mann Ko |
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Department of Pediatrics, Paik Hospital in Seoul, Inje Medical College, Seoul, Korea |
| 정상혈압을 가진 역류성 신병증 (Reflux Nephropathy)
환아에서의 Renin 활성도 |
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이종국, 고광만 |
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인제대학부속 백병원 소아과학교실 |
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Received: 25 November 1987 • Accepted: 21 January 1988 |
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| Abstract |
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Peripheral renin activity was measured in 11 children with normotensive reflux nephropathy and 20
normal children to disclose the abnormality of the renin-angiotensin system in the patient group. 9
children among the patient group were allocated to single-dose captopril test for the assessment of the
response to the test in patients with normotensive reflux nephropathy.
1. Contrary to the significant negative correlation between PRA and age in the normal control(r=-
0.66, p< 0.001), there was no negative correlation between them in the patient group(r=-0.1).
2. The correlation between PRA and mean Na excretion were not signiticant in the patient group
and control group.
3. There were 2 types of response to single-dose captopril test on patients with normotensive RN,
namely, Hyperresponders and non-Hyperresponders.
4. Only the initial level of PRA before captopril loading could indicate the responsiveness of
patients to the captopril test. With regard to age, mean Na excretion and severity of renal scar, there
were no significant difference between Hyperresponders and non-Hyperresponders.
5. Long-term follow-ups are needed to confirm whether hyperresponsiveness to oral single-dose
captopril test is related to the risk of hypertension. Nevertheless, this test seems to be very helpful
to identify the abnormality of renin activity in patients with RN. |
| Key Words:
Plasma renin activity, Reflux Nephropathy, Captopril test |
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