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Change of Clinical Feature of Typhoid Fever in Children.

Journal of the Korean Pediatric Society 1988;31(5):566-576.
Published online May 31, 1988.
Change of Clinical Feature of Typhoid Fever in Children.
Sung Oh Kim, Yong Joo Kim, Woo Kill Lee, Chong Moo Park
Department of Pediatrics Hanyang University College of Medicine, Seoul, Korea
소아 장티프스 임상상의 시대적 변화
김성오, 김용주, 이우길, 박종무
한양대학교 의과대학 소아과학교실
Received: 19 November 1987   • Accepted: 31 December 1987
We studied clinically on changing pattern of 256 patients with typhoid fever in children, who were hospitalized in the Department of Pediatrics Hanyang University Hospital for 14 years 8 months from May 1972 to December 1986. We divied two group: one, in the seventies (1972-1979), 175 patients; the other, in the eighties (1980 -1986), 81 patients and compared with each other. The results were as follows: 1) The annual incidence was markedly decreased in the eighties (0.35%) than seventies (1.41%), (p< 0.0001). 2) In the seventies, the highest incidence was noted in the summer season, but in the eighties, relatively evenly distributed all through the season. 3) The disease was more prevalent in male than female and highest in the age of 6-9 years in both eras. 4) The complicated or associated diseases in typhoid fever were more increased in the eighties (42.0%) than in the seventies (13.7%), (p<0.0001). But there is no significant changes in each disorder. 5) On sensitivity test to antibiotics against Salmonella typhi isolated from blood cultures, sensitivity to Ampicillin was slightly increased but not significantly changed in both eras, but in the eighties, sensitivities to Chloramphenicol and Gentamicin were more increased and sensitivities to Carbenicillin, Penicillin, and Streptomycin were more decreased and sensitivities to Cefamezin, Amikacin, and Trimethoprim/Sulfamethoxazole were 100%. 6) There was no significant changes between two eras in the duration from onset to admission, mostly within 1 week, in clinical manifestations on admission, and laboratory findings such as hemoglobin, leukocyte count, bacterial cultures and Widal test.
Key Words: Changing pattern, Children, Typhoid fever

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