| The Prevalence of Antithyroid Autoantibodies in Korean Children. |
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Bung Hai Ahn, Sei Won Yang, Hyung Ro Moon |
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Department of Pediatrics, Seoul National University, College of Medicine, Seoul, Korea |
| 한국 소아의 항갑상선자가항체
양성률에 대한 연구 |
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안병해, 양세원, 문형로 |
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서울대학교 의과대학 소아과학교실 |
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Received: 17 November 1987 |
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| Abstract |
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The prevalence of antithyroid autoantibodies and the relationship between the presence of
autoantibodies and thyroid functions were studied in 752 Korean children of 10 to 15 years of age with
normal thyroids. Antimicrosomal antibodies (AMA) were measured by the indirect agglutination
technique using artificial gelatin particle carriers sensitized with thyroid microsomal antigen and
antithyroglobulin antibodies (ATA) by the tanned red cell hemagglutination technique.
Circulating AMA were detected in 3.3% and ATA in 1.0%. The prevalences of AMA and ATA were
2.9% and 0.5% in 431 boys, and 3.7% and 1.5% in 321 girls, respectively. Neither antibody showed any
significant sex or age difference. High titers equal to or greater than 1:100² of one both of the
antibodies were not detected. The serum T3, T4, and TSH values (mean± standard deveiation) of 26
antibody postive children were 120.1 ±47.2 ng% 9.2 ±2.7µg% and 2.7 ±1.5 µU/ml and those of 36
antibody negative children were 136.4 ±35.8 µg% and 2.9±1.8 µU/ml, respectively. There was no
difference in the seurm T3, T4 and TSH values between the antibody positive and negative groups.
It might be concluded that the incidentally found antithyroid antibodies in single determination in
children without apparent thyroid abnormality may not have the same clinical predictive significance
with regard to the development of autoimmune thyroid diseases as in adults, and appropriate
follow-up for the time course of autoantibody and thyroid function will elucidate the prognostic
significance of antithyroid autoantibodies in relation to the development of overt hypothyroidism in
children. |
| Key Words:
Antithyroid autoantibody, Thyroid function test |
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