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A Study on Minimal Change Nephrotic Syndrome in Children.

Journal of the Korean Pediatric Society 1988;31(2):220-226.
Published online February 28, 1988.
A Study on Minimal Change Nephrotic Syndrome in Children.
Yong Choi1, Hong Jin Lee1, Hae Il Cheong1, Kwang Wook Ko1, Hyun Soon Lee2, Yong Il Kim2
1Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea
2Department of Pathology, College of Medicine, Seoul National University, Seoul, Korea
소아기의 미소병변(微小病變) 신증후군에 관한 연구 -병리학적 세(細)분류의 임상적 의의-
최용1, 이홍진1, 정해일1, 고광욱1, 이현순2, 김용일2
1서울대학교 의과대학 소아과학교실
2서울대학교 의과대학 병리학교실
Received: 4 September 1987
Abstract
To assess the clinical significance of histopathologic variants of minimal change nephrotic syn- drome (MCNS) by light microscopic findings, 148 biopsy proven MCNS patients, who were admitted to Seoul National University Hospital between the period from January 1976 to December 1986, were analyzed according to clinical findings, steroid responsiveness, and follow up status in relation to the pathologic variants. The followings are summary and conclusion. 1) Significantly larger proportion of patients with FGO had onset before 6 years of age. 2) Hematuria was more common in patients with FTC and MMH than with Nil and FGO. 3) Hypertension, selectivity index and elevated Scr at admission were not different among the categories. 4) Unresponsiveness to initial treatment was significantly more common in patients with FTC and MMH. However the differences in the proportions of subsequent nonresponders were not remarkable among the histological categories. 5) Five (3.8%) out of 148 paitients died during the follow up period. With the above findings, clinical significance of subgrouping histologic variants in MCNS seems to be less prominent as the follow up period is extended.
Key Words: Minimal Change Nephrotic Syndrome


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