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Clinical Analysis of Congenital Malformations in the Newborn Infant.

Journal of the Korean Pediatric Society 1988;31(1):72-77.
Published online January 31, 1988.
Clinical Analysis of Congenital Malformations in the Newborn Infant.
Hoon Chang, Chae Hwa Lee, In Kyung Sung, Byung Churl Lee, Sung Hoon Cho
Department of Pediatrics, Catholic University Medical College, Seoul, Korea
선천성기형에 관한 임상적 고찰
장훈, 이채화, 성인경, 이병철, 조성훈
가톨릭의대 의학부 소아과학교실
Received: 23 September 1987
Congenital malformations are still one of the leading problems of neonatal death and illness. But, we have only a few data for about it, because of difficulty in the exact analysis of the incidence and etiologic factors. During the period of 6 years, between January 1980 and December 1985, a clinical study about the general incidence of congenital malformations was done on 50, 979 live borns delivered at 7 hospitals of Catholic Medical Center. The results were as follows: 1) The incidence of congenital malformations was 2.1% and the frequency of male congenital malformations was 2.3% and that of females was 1.8%. 2) The incidence of malformations in low birth weight infants (4.0%) was higher than that of normal (1.9%) and high birth weight infants (1.6%). 3) In the prematures below 37 weeks, malformations occured more frequently than in the mature infants above 37 weeks (4.5% vs 1.9%). 4) The incidence of malformations was 2.0% and 2.8% in below and above 35 years of maternal age groups, respectably. 5) Among 1,050 malformed infants, 277 (26.4%) had more than one malformation. 6) Gastrointestinal system was the most frequently involved system (24.4%) and then musculo- skeletal system, skin, cardiovascular system in the order. 7) The most frequently involved system which caused the neonatal death was central nervous system (39.8% of 191 total death). 8) Major congenital malformations were 64.8% and minor malformations were 35.2%.
Key Words: Congenital malformations.

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