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Clinical Study of Congenital Hypothyroidism.

Journal of the Korean Pediatric Society 1987;30(12):1401-1408.
Published online December 31, 1987.
Clinical Study of Congenital Hypothyroidism.
Byung Churl Lee, Soon Joo Lee, Sung Hoon Cho
Department of Pediatrics Catholic Medical College, Seoul, Korea
선천성 갑상선기능저하증에 대한 임상적 고찰
이병철, 이순주, 조성훈
가톨릭의대 의학부 소아과학교실
We reviewed 24 patients with congenital hypothyroidism to observe the etiology, clinical symptoms and signs, bone age, height age, the degree of mental retardation and growth velocity after treatment form Jan. 1983 to June 1987. The results were as follows: 1) The male to female ratio was about 1:3.8. The cases diagnosed under 1 year old were only 12.5%. 2) In etiologic classification, thyroid dysgenesis was 20 cases (83.3%) and dyshormonogenesis was 4 cases (16.7%). Hypoplastic gland (41.7%) was the most common cause in the thyroid dysgenesis. 3) Constipation (91.6%), slow growth rate (87.5%) and lethargy (79.2%) were the most common symptoms and mental retardation (91.6%), distended abdomen (87.5%) and delayed dentition (82.3%) were the most common signs of congenital hypothyroidism. 4) Height and bone age was remarkedly retarded in all cases except 2 cases diagnosed under 8 weeks of age. 5) All cases diagnosed and treated after 8 weeks of age showed mild and moderate mental retardation. 6) All cases have shown good responses after sodium levothyroxine therapy. 7) In the 15 cases diagnosed beyond age two years, mean annual growth velocity was 8.2±3.2 cm during the first 3 years after treatment.
Key Words: Congenital hypothyroidism

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