| Immunogenecity of Low-Dose Administration of Hepatitis B Virus Vaccine in School Aged Group. |
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Young Mo Sohn1, Pyung Kin Kim1, Kyung Soon Song2 |
1Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea
2Department of Clinical Pathology, Yonsei University College of Medicine, Seoul, Korea |
| 학동기 연령층에서 B형 간염 백신 감량 접종후의 면역효과에 대한 연구 |
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손영모1, 김병길1, 송경순2 |
1연세대학교 의과대학 소아과학교실
2연세대학교 의과대학 임상병리학교실 |
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| Abstract |
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For evaluation of immunogenecity of low-dose of hepatitis vaccine-prepared by Korea Green Cross
Corporation 74 school aged children were given routine schedule (0, 1, 6 months). A dose of 5
microgram was administered intramuscullary in the cases of age under 10 yrs of age and 10
microgram was administered in the cases over 11 yrs of age. An adequate follow-up observation
of antibody titer by RIA was possible at 1, 2, 6, 7, 12 months after the first injection. In addition,
we followed up anti-HBs titer of 45 children whose anti-HBs was positive at the screening survey.
The results were as followes:
1) The anti-HBs positive rate was 95.6% (43/45) in the 5 microgram group and 100% (29/29) in
10 microgram group at the time of 12 months after the first injection. The effective rate
(seroconversion rate 10 R.U.) was 68.9% (31/45) in the 5 microgram group and 79.3% (23/29) in the
10 microgram group.
2) The geometric mean anti-HBs titer at the 12 months after the first injection was 24.3 R.U.
in 5 microgram group and 37.3 R.U. in the 10 microgram group.
3) Seronegative conversion rate of the children who has isolated anti-HBs at screening survey
was 23.8% (5/21) at 12 months later. Especially 80% of seroconversion rate was observed in the
5 cases who had anti-HBs titer below 10 R.U.
According to the above results, we have evaluated the low-dose administration of hepatitis Bvaccine
in school aged children was effective for immunogenecity of this vaccine. But further
follow-up of antibody titer must be evaluated and we found that in the most of isolated low titeranti-HBs cases, their antibody disappeared within 12 months.
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| Key Words:
Hepatitis B Vaccine, Immunogencity.
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