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Effect of Simultaneous Administration of Hepatitis B Vaccine with DPT and Oral Polio Vaccine

Journal of the Korean Pediatric Society 1998;41(4):451-455.
Published online April 15, 1998.
Effect of Simultaneous Administration of Hepatitis B Vaccine with DPT and Oral Polio Vaccine
Hyo Geun Ju, Young Youn Choi, Jae Sook Ma, Tai Ju Hwang
Department of Pediatrics, College of Medicine, Chonnam University Hospital, Kwangju, Korea
디피티와 동시에 접종한 B형 간염 백신의 효과
주효근, 최영륜, 마재숙, 황태주
전남대학교 의과대학 소아과학교실
Correspondence: 
Hyo Geun Ju, Email: 1
Abstract
Purpose
: The universal vaccination against hepatitis B during early infancy is the only effective way to control hepatitis B infection in highly endemic areas in Korea. The purpose of this study was to assess the effectiveness of simultaneous hepatitis B vaccination with DPT and oral polio at 2, 4, 6 months of age in babies of HBs antigen negative mothers.
Methods
: One hundred and eighty-one infants who were admitted to the Neonatal Intensive Care Unit(NICU), Chonnam University Hospital from August, 1994 to December, 1995 were enrolled in this study. Infants received Hepavax-B 0.5ml(10μg) at contralateral thigh intramuscularly, simultaneously with DPT vaccination. Antibody was assessed by MEIA(microparticle enzyme immunoassay) at seven to nine months of age.
Results
: The seroconversion rate of Hepatitis B after vaccination was 98.3%. There were no significant differences in positive rate of antibody according to gestational age, birth weight and sex. Seroconversion rate to hepatitis B in twins was lower than in singlets. Twenty-two infants among 23 infants, who were able to assess antibody titer, showed effective antibody titer, above 100mIU/ml.
Conclusion
: The results suggest that the simultaneous administration of hepatitis B vaccine with DPT/TOPV is very effective and simplifies schedule. Moreover, this schedule will improve the compliance of vaccination.
Key Words: Simultaneous hepatitis B vaccination, Seroconversion rate


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