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Hodgkin’s Disease in Children

Journal of the Korean Pediatric Society 1986;29(12):1352-1359.
Published online December 31, 1986.
Hodgkin’s Disease in Children
Soo Jong Hong, Hyo Seop Ahn, Chang Yee Hong
Department of Pediatrics, College of Medicine, Seoul National University
소아의 Hodgkin 병
홍수종, 안효섭, 홍창의
서울대학교 의과대학 소아과학교실
Abstract
Twenty one cases of Hodgkin’s disease under 15 years of age who were admitted to Dept, of Ped. of Seoul National University Hospital from Jan. 1976 to Dec. 1985 were reviewed and analysed. One hundred and five cases of non-Hodgkin’s lymphoma were seen during the same period. 1) The ratio of non-Hodgkin’s lymphoma to Hodgkin's disease was 5:1. 2) The age ranged from 18/12 years to 152/12 years, with mean age of 9 years. There were only three cases under 5 years old. 3) The ratio of male to female was 6 : 1. Boys were more prevalent than girls. 4) Biopsy sites were cervical lymph nodes in 17 cases, chest wall mass in 1 case, abdominal mass in 2 cases and spinal cord mass in 1 case. 5) Histopathologic types cwisisted of 12 mixed cellularity(57%), 5 nodular sclerosis(24%), 4 lymphocytic predominance(19%), and lymphocytic depletion type was not seen. 6) Pathologic stage consisted of 1 stage I A, 1 stage IB, 2 stage IIA, 1 stageIIB, 4stage IIA, 1 stage IIB and 4 stage IIIA ,1 stage IIIB and 4 stage IV 7) Treatment consisted of 3 radiation therapy only, 11 radiation therapy and chemotherapy, and 6 chemotherapy only. The longest relapse free survival time was 9 years in 2 cases. Second malignant neoplasm has not been noted. ABVD is an alternative salvage regimen for C-MOPP resistant Hodgkin’s disease.
Key Words: Hodgkin` s disease, Histopathologic type, Relapse free survival time, ABVD, C-MOPP, radiation therapy.


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