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Experimental Study of Influence of Some Barbiturate Derivatives on the Renal Function.

Journal of the Korean Pediatric Society 1985;28(8):773-782.
Published online August 31, 1985.
Experimental Study of Influence of Some Barbiturate Derivatives on the Renal Function.
Jong Duck Kim, Byeung Sang Choi, In Soo Choi, Heon Sook Lee, Jung Soo Kim
Dept, of Pediatrics, Physiology, Jeonbug National University Medical School
Barbiturate계 약물이 신장기능에 미치는 영향에 관한 실험적 연구
김종덕, 최병상, 최인수, 이현숙, 김정수
전북대학교 의과대학 소아과학교실
One of the most frequently used anesthetics in the laboratory or clinical practice is barbiturate derivatives. There have been many reports on the renal effects of barbiturate anesthesia, but they still controversial. It has been reported that the central administration of very small dose of thiopental sodium influence the renal function directly. To compare possible different renal effects of the barbiturates of the molecular basis of its chemical structure, experiments have been done in unanesthetized rabbits. 1)Pentobarbital and thiopental sodium administrated intracerebroventricularly induced a marked natriuresis, but diuresis was not appeared by pentobarbital sodium. Free water clearance was not changed by thiopental sodium, but had a tendency to decrease by pentobarbarbital sodium without significance. 2)Phenobarbital, having a phenyl radial at R6b position of barbituric acid, did not induce any change of renal function. Sodium barbital, having a ethyl radical at R5b position, induced decrement of urinary flow and free water clearance without significance. These data suggest that the lipid solubility and/or the radicals at the position of barbituric acid may be responsible for the different renal effects of barbiturates administered into lateral cerebral ventricle.
Key Words: Barbiturate derivatives, Renal function

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