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Clinical Studies on Hepatotoxicity of Antituberculous Durgs in Children.

Journal of the Korean Pediatric Society 1985;28(5):455-462.
Published online May 31, 1985.
Clinical Studies on Hepatotoxicity of Antituberculous Durgs in Children.
Seong Sook Kim, Ki Sup Chung
Department of Pediatrics,Yonsei University Medical Center
소아에서 항결핵제 투여로 인한 간독작용 (hepatotoxicity) 에 대한 임상적 고찰
김성숙, 정기섭
연세대학교 의과대학 소아과학교실
A clinical studies were performed on hepatotoxicity of antituberculous drugs in 155 cases of tuberculous patients under 15 years who had been admitted to Pediatric Department of Yonsei University Medical Center during 4 years period between January, 1979 and December, 1982. The results were obtained as follows; 1) Hepatotoxicities were observed on 20 cases among 155 cases. They all belonged to the group taken isoniazid(INH) and rifampicin(RIF)-containing drug regimens, so they constituted 17% among the group(117 cases) taken INH and RIF-containing drug regimens. No patient treated with non RIF-containing regimens showed hepatotoxicity. 2) Among 117 cases taken INH and RIF-containing drug regimens, mild tuberculous infections(primary pulmonary tuberculosis, lymphatic tuberculosis) were 20 cases, among them 2 casesfio%) showed hapatotoxicity, whereas severe tuberculous infections(multiple organ involvement, progressive pulmonary tuberculosis, tuberculous meningitis, bone and joint tuberulosis, et al) were 97 cases, among them 18 cases(19%) showed hepatotoxicity. 3) Hepatotoxicity was found in 14 cases(18%) among 79 patients taken higher dose(more t- han 16 mg/kg/day) of INH and RIF, whereas 3 cases(16%) among 18 patients taken lower dose(less than 15 mg/kg/day).
Key Words: Antituberculous drugs, Hepatotoxicity

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