Journal of the Korean Pediatric Society 1983;26(9):916-921.
Published online September 30, 1983.
Nephrogenic Diabetes Insipidus occurred in 2 Brother.
Jin Heon Kim, Cheol Won Park, Bong Soo Lee, Chang Soo Ra
Department of Pediatrics, College of Medicine, Chosun University
형제에서 발생한 신성뇨붕증 2례
김진헌, 박철원, 이봉수, 라창수
조선대학교 의과대학 소아과학교실
Nephrogenic diabetes insipidus is a congenital hereditary disorders in which the kidney do not respond to vasopressin, and the disease occurs principally in males and is probably inherited by Xlinked recessive mode. We experienced two cases of nephrogenic diabetes insipidus occurred in brothers. The clinical manifestations were extreme thirst and frequent urination of large volume of dilute urine, approximately 5,500ml per day with specific gravity 1.000. The diagnosis was made by water restriction and pitressin test. Administration of chlorothizide diuretics in combination with reduced sodium intake led to reduction in urinary volume and to increased urinaryconcentration. We report neprogenic diabetes insipidus with brief review of literatures.
Key Words: Nephrogenic diabetes insipidus.

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