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Five Cases of Hemorrhagic Disease of Infancy.

Journal of the Korean Pediatric Society 1982;25(5):518-522.
Published online May 31, 1982.
Five Cases of Hemorrhagic Disease of Infancy.
Jung Sook Moon, Eun Hee Koh, Sang Man Shin, Sang Jhoo Lee
Department of Pediatrics, Soon Chun Hyang College, Seoul, Korea.
영아기 출혈성 질환 5 례
문정숙, 고은희, 신상만, 이상주
순천향대학 의학부 소아과학교실
A hemorrhagic disease due to acquired prothrombin complex deficiency is presented in five infants from 3 weeks to 2 months of age. There are 2 cases of intracranial hemorrhage, 1 case of hemothorax, 2 cases of gastrointestinal bleeding, 1 case of epistaxis and 3 cases of petechia, purpura or bleeding from injection site. After the administration of vitamin K, bleeding ceased and prolonged prothrombin time was corrected promptly. Vitamin K dependent coagulation factor deficiency due to vitamin K deficiency is accounted for the pathogenesis of bleeding. Diarrhea, treatment with antimicrobial agents and a diet low in vitamin K are suggested as etiologic factors acting together.
Key Words: Hemorrhagic disease,infancy,Vitamin K

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