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Bronchial asthma, Atopic dermatitis, HLA type.

Journal of the Korean Pediatric Society 1982;25(5):467-476.
Published online May 31, 1982.
Bronchial asthma, Atopic dermatitis, HLA type.
Yun Mo Sohn, Han Ku Moon, Myung Hi Shin, Ji Sub Oh
Department of Pediatrics, Wallace Memorial Baptist Hospital, Busan, Korea.
세균성 이질의 항생제 효과에 관하여
손연모, 문한구, 신명희, 오지섭
부산 왈레스기념 침례희병원 소아과
We observed 285 cases of culture proved shigellosis from Jan. 1978 to July 1981 at W.M.B.H. in Busan. We specially observed the clinical and bacteriological response to Oxolinic acid in 59 cases from Jan. to July 1981. The following results were obtained. 1. The most commonly isolated shigella strains was Sh. flexneri (85.3%) followed by Sh. sonnei (7.4%), Sh. boydii (4.2%) and Sh. dysenteriae(3.2%). 2. Antibiotic sensitivity test revealed that more than 90% of strains were resistant to Tetracycline, Chloramphenicol and Ampicillin. Resistance strains to Gentamycin and Oxocid were found in less than 12.2% and 14.3% respectively. 3. The multiple antibiotic resistant strains were observed in about 80% of 59 strains, which were resistant to 3~5 antibiotics. The most of these strains were resistant to Ampicillin, Chloramphenicol and Tetracycline. In 3 cases it was resistant to all kinds of antibiotics but oxolinic acid. 4. Oxolinic acid showed growth-inhibitory zone of more than 11 mm with the concentration of 2mcg/ml in 95% and M.I.C. value of less than 0.76mcg/ml in 90%. 5. After administration of Oxolinic acid, there was clinical response within 2 days in 76.5% and conversion to negative stool culture within 2days in 68.8%. 6. Compared with placebo group, there was parallel clinical and bacteriologic effectiveness between Oxolinic acid and Rifampin.
Key Words: Shigellosis, Oxolinic acid

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