| Clinical Observation of Hemolytic Anemia in Children Except Isoimmunization. |
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Hak Yong Kim, Young Mo Sohn, Kwan Sub Chung, Kir Young Kim, Duk Jin Yun |
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Department of Pediatrics, Yonsei University College of Medicine |
| 소아 용혈성 빈혈의 임상적 고찰(동종 면역성 빈혈은 제외) |
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김학용, 손영모, 정관섭, 김길영, 윤덕진 |
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연세의대 소아과 |
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| Abstract |
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Hemolytic anemia is caused by early destruction of red cells and there are many etiologies,ecently, prosthetic devices are used frequently to correct cardiac diseases and they also cause hemolytic anemia.
We performed clinical analysis of 74 patients with hemolytie anemia who had been diagnosed at Severance hospital in recent 10 years. Results were as follows: 1)In 74 cases, male were 46 and female were 28 cases. The highest incidence by age was noticed as 51.4% in the group under the age of 1 year. 2)Etiologically, hereditary spherocytosis 6, hereditary ellitocytosis 2, PNH 3, DIC 38,hemolytic uremic syndrome 7, mechanical hemolysis 4, autoimmune hemolytic anemia 2,-unclassified 12 cases were present. 3)Bone marrow examination which was performed in 24 cases revealed marked erythroid hyperplasia (mean M/E ratio 1 : 3.4). 4)Coombs test was positive in 2 cases of autoimmune hemolytic anemia. Ham test and sucrose lysis test were positive in 3 cases of PNH. No abnormal hemoglobin was deted. by hemoglobin electrophoresis. 5)RBC osmotic fragility curve in patients with hereditary spherocytosis and elliptocytosis showed marked shift to right side. 6) There were clinical improvement in almost all patients except patients with DIC and hemolytic uremic syndrome. 7) Hemolytic anemia which developed after cardiac surgery occured in 4 eases. 2 cases were not followed up, but another 2 cases were cured by repair of detached patches of VSD.
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| Key Words:
Hemolytic anemia, Mechanical hemolytic anemica, TOF, VSD |
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