Journal of the Korean Pediatric Society 1980;23(11):956-961.
Published online November 15, 1980.
Massive Hepatic Necrosis Associated with Halothane Anesthesia.
Kyo Sun Kim1, Pyung Kil Kim1, In Joon Choi2
1Department of pediatrics, Yonsei University College of Medicine, Seoul, Korea.
2Department of pathology, Yonsei University College of Medicine, Seoul, Korea.
Halothane 마취제와 동반된 간 괴사
김교순1, 김병길1, 최인준2
1연세대학교 의과대학 소아과학교실
2연세대학교 의과대학 병리학 교실
Two cases in which postoperative hepatic necrosis followed by halothane(fulthane) anesthesia are presented. Case 1 was 3 dar-old neonate who was performed corrective surgery for jejunal atresia under the halothane anesthesia. He was placed with hyperalimentation just after operation, and was relatively well. He died on postoperative 11 days. Necropsy matrial was obtained from liver. Histologic finding of liver disclosed massive cental hemorrhagic necrosis. Case 2 was a 17 year-old boy who was performed corrective open heart surgery for TOF under the halothane anesthesia, He developed oliguria just after operation. On postoperative 1 day, hepatocellular and renal dysfunction were found, and peritoneal diaysis performed. He died on postoperative 3 day. Necropsy matrials were obtained from liver and kidney-Liver disclosed massive central hemorrhagic necrosis. Kidney showed intact glomeruli and proximal and distal convoluted tubular cells were degenerated. The configuration of tubular basement membrane was not clear. These considered to be acute tubular necrosis, ischemic type.

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