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A Study of the LDH Activities ad Isoenzyme-Pattern in Cerebrospinal Fluid of various Central Nervous System Diseases.

Journal of the Korean Pediatric Society 1979;22(4):255-261.
Published online April 15, 1979.
A Study of the LDH Activities ad Isoenzyme-Pattern in Cerebrospinal Fluid of various Central Nervous System Diseases.
Ha Baik Lee
Dept. of Pediatrics, College of Medicine, Hang Yang University, Korea.
中極神經系 感染性 疾患에 있어서 腦脊髓液內 LDH 活性度 및 isoenzymes 分劃像에 關한 硏究
李夏白
漢陽大學校 醫科大學 小兒科學敎室
Abstract
The Lactic Dehydrogenase(LDH) and its isoenzyme activities in Cerebrospinal Fluid(CSF) of 50 patients with Cental Nervous System (CNS) disease were studied to explore the possibility of difference among the various meningitis and their relationshiop to its prognosis, and to compare with 12 patients without CNS infection as control group The results obtained were as follows : 1) The levels of total LDH, LDH 1 and LDH 5 in control group were within normal limit of 18.3 units, 51.8% and 0% respectively. 2) The LDH activities were highest at purulent meningitis group, mederate at T.B. meningitis group and lowest at aseptic meningitis group. 3) Prognosis was poor in the group with highly elevated LDH activities and LDH5 values, which included purulent meningitis and T.B. meningitis accompanied by unconsciousness, and good prognosis was noted with normal LDH activities in aseptic meningitis. 4) The LDH activities and LDH5 values of the partially treated purulent meningitis group were significantly elevated compared to those of T.B. and aseptic meningitis groups 5) The LDH activities became normalized in a week of appropriate treatment for purulent meningitis and in 7 weeks treatement for T.B. meningitis.


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